Author

B. Holmes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Benavides-Serrato· 2 shared J. Gera· 2 shared A. Lawson· 1 shared A. Macpherson· 1 shared C. M. Deane· 1 shared D. Goldfarb· 1 shared D. I. Svergun· 1 shared E. Wilkerson· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

A. Benavides-Serrato

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Author profile →

4 papers

Recent·Most cited

Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC

N. Wamsley, E. Wilkerson, L. Guan, K. LaPak, T. Schrank, B. Holmes, R. Sprung, P. E. Gilmore, S. Gerndt, R. Jackson, R. Paniello, P. Pipkorn, S. V. Puram, J. Rich, R. R. Townsend, , M. B. Major

This paper develops a targeted proteomics assay to quantify NRF2 pathway components and clinical biomarkers in HNSCC, identifying correlations between NRF2 activity, HPV infection, and immune markers.

bioRxiv · Mar 13, 2023Cancer Biology

The allosteric modulation of Complement C5 by knob domain peptides

A. Macpherson, M. Laabei, Z. Ahdash, M. A. Graewert, J. Birtley, S. Schulze, S. Crennell, S. Robinson, B. Holmes, V. Oleinikovas, P. H. Nilsson, J. Snowden, V. Ellis, T. E. Mollnes, C. M. Deane, , J. van den Elsen

This study shows that knob domain peptides modulate complement C5 through allosteric mechanisms, revealing new therapeutic inhibitors and introducing knob domains as low molecular weight antibody fragments.

bioRxiv · Oct 24, 2020Immunology

Targeting the mTORC2 signaling complex in B cell malignancies.

W. Liao, G. Jordaan, A. Benavides-Serrato, B. Holmes, J. Gera, S. Sharma

This study identifies novel inhibitors that disrupt the mTORC2 complex and induce apoptosis in chronic lymphocytic leukemia cells more effectively than existing treatments.

bioRxiv · Mar 5, 2019 · PreprintCancer Biology

mTORC2/AKT/HSF1/HuR Constitute A Feed-Forward Loop Regulating Rictor Expression And Tumor Growth In Glioblastoma

B. Holmes, A. Benavides-Serrato, R. S. Freeman, K. A. Landon, T. Bashir, R. N. Nishimura, J. Gera

This study identifies a feed-forward loop involving mTORC2/AKT/HSF1/HuR that regulates Rictor expression and promotes glioblastoma growth.

bioRxiv · May 19, 2017Cancer Biology