L. Guan

RUNX1 Isoforms Regulate RUNX1 and Target-Genes Differentially in Platelets-Megakaryocytes: Association with Clinical Cardiovascular Events

This study investigates how RUNX1 isoforms B and C regulate RUNX1 and its target genes in megakaryocytes and platelets, and links these regulatory patterns to clinical cardiovascular events.

Distinct roles of the major binding residues in the cation-binding pocket of MelB

This study identifies the distinct roles of key residues in the cation-binding pocket of MelBSt through structural analysis, free energy simulations, and biochemical experiments.

Therapeutic effect of dietary interventions on senescence in animals and humans: A systematic review

This review evaluates dietary interventions for reducing cellular senescence in animals and humans, finding resveratrol, vitamin E, and soy protein isolate show promise in animal studies, but human evidence is limited.

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides

This paper identifies Acb2 as a phage-encoded protein that sequesters multiple cyclic dinucleotides and trinucleotides, inhibiting CBASS immunity.

Early cellular and molecular signatures correlate with severity of West Nile Virus infection

The paper identifies cellular and molecular signatures associated with varying severities of West Nile Virus infection using multi-omics analysis of immune responses.

Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC

This paper develops a targeted proteomics assay to quantify NRF2 pathway components and clinical biomarkers in HNSCC, identifying correlations between NRF2 activity, HPV infection, and immune markers.

Direct determination of oligomeric organization of integral membrane proteins and lipids from intact customizable bilayer

This paper develops a platform for analyzing integral membrane proteins and lipids in intact membranes using native mass spectrometry, showing how lipid binding and membrane composition affect protein function.

Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell self-renewal, differentiation and survival

This study shows that ALDH3A1 deficiency causes mitochondrial dysfunction and impairs salivary gland stem cell self-renewal, differentiation, and survival.

Molecular recognition of sugar binding in a melibiose transporter MelB by X-ray crystallography

This paper presents two X-ray crystal structures of a MelB mutant, revealing the molecular recognition mechanism for sugar binding and the structural basis for cooperative binding in Na+-coupled MFS transporters.

Auxin Regulation and MdPIN Expression during Adventitious Root Initiation in Apple Cuttings

This study investigates auxin regulation and MdPIN gene expression during adventitious root formation in apple cuttings, revealing their roles in cell division and organogenesis.