J. Rich

Timp2 loss-of-function mutation and TIMP2 treatment in murine model of NSCLC: modulation of immunosuppression and oncogenic signaling

TIMP2 treatment compensates for TIMP2 mutation to reveal immunomodulatory and oncogene regulation that inhibits tumor growth and metastatic niche formation.

Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC

This paper develops a targeted proteomics assay to quantify NRF2 pathway components and clinical biomarkers in HNSCC, identifying correlations between NRF2 activity, HPV infection, and immune markers.

The landscape of extrachromosomal circular DNA in medulloblastoma

This study identifies ecDNA in 18% of medulloblastoma patients, linking it to higher relapse and mortality rates and suggesting enhancer rewiring as an oncogenic mechanism.

Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches

This study identifies distinct lipid metabolism patterns in glioblastoma stem and non-stem cells across different tumor microenvironments, highlighting potential therapeutic targets.

Field-based body temperatures reveal behavioralthermoregulation strategies of the Atlantic marsh fiddler crab Minuca pugnax

This study measures body and environmental temperatures of Atlantic marsh fiddler crabs to show how they use burrows for thermoregulation and how climate change may affect their behavior.

A novel interplay between GEFs orchestrates Cdc42 activation in cell polarity and cytokinesis

The paper identifies a crosstalk mechanism between Gef1 and Scd1 GEFs that spatially regulates Cdc42 activation to control cell polarity and cytokinesis in fission yeast.