Author

B. Khambu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

X.-M. Yin· 3 shared G. Liu· 2 shared X. Chen· 2 shared Z. Dong· 2 shared A. Mercer· 1 shared G. Guo· 1 shared H. Hong· 1 shared J. Wan· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersPharmacology & Toxicology

X.-M. Yin

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3 papers

Recent·Most cited

Impaired hepatic autophagy exacerbates xenobiotics induced liver injury

K. Byrnes, N. T. Bailey, A. Mercer, S. Joshi, G. Liu, X.-M. Yin, B. Khambu

This study shows that impaired hepatic autophagy worsens xenobiotic-induced cholestatic liver injury by promoting p62-Ub-IHB accumulation and suppressing FXR.

bioRxiv · May 27, 2022 · PreprintPharmacology & Toxicology

Gut dysbiosis protects against liver injury in autophagy deficient mice by FXR-FGF15 feedback signaling

S. Yan, B. Khambu, X. Chen, Z. Dong, G. Guo, X.-M. Yin

This study shows that gut dysbiosis reduces liver injury in autophagy-deficient mice through FXR-FGF15 signaling, suggesting caution in antibiotic use during liver disease.

bioRxiv · May 12, 2020Pathology

The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors

B. Khambu, H. Hong, S. Liu, G. Liu, X. Chen, Z. Dong, J. Wan, X.-M. Yin

This study investigates how HMGB1 and RAGE promote tumor growth in autophagy-deficient livers by altering the tumor microenvironment and mitochondrial function.

bioRxiv · Nov 25, 2019Cancer Biology