B. Lina

Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion

This study characterizes SARS-CoV-2 variants XBB and BA.2.86/JN.1, finding they show increased fitness and antibody evasion while maintaining antiviral sensitivity.

A novel effective live-attenuated human metapneumovirus vaccine candidate produced in the serum-free suspension DuckCelt-T17 cell platform

This study evaluates the use of DuckCelt-T17 avian cells for producing a live-attenuated HMPV vaccine candidate, showing its efficiency and scalability.

Characterization of SARS-CoV-2 ORF6 deletion variants detected in a nosocomial cluster during routine genomic surveillance, Lyon, France

This study identifies two SARS-CoV-2 ORF6 deletion variants from genomic surveillance, showing nosocomial transmission and comparable replication kinetics but no significant clinical impact.

Human Respiratory Syncytial Virus-induced immune signature of infection revealed by transcriptome analysis of clinical pediatric nasopharyngeal swab samples

This study identifies an HRSV-induced immune signature in pediatric nasal wash samples using transcriptome analysis.

Transcriptional profiling of immune and inflammatory responses in the context of SARS-CoV-2 fungal superinfection in a human airway epithelial model

The paper compares the transcriptional responses of SARS-CoV-2 and Aspergillus superinfection in human airway epithelial models, identifying unique immune and inflammatory signatures.

Broad-spectrum antiviral activity of naproxen: from Influenza A to SARS-CoV-2 Coronavirus

This study evaluates naproxen's antiviral activity against SARS-CoV-2 and Influenza A virus, showing it inhibits viral replication and protects respiratory epithelia.

Characterization and treatment of SARS-CoV-2 in nasal and bronchial human airway epithelia

The paper characterizes SARS-CoV-2 infection in nasal and bronchial airway epithelial models and evaluates the antiviral efficacy of remdesivir and its combination with diltiazem.

Molecular characterization of SARS-CoV-2 in the first COVID-19 cluster in France reveals an amino-acid deletion in nsp2 (Asp268Del)

The paper characterizes a SARS-CoV-2 cluster in France, identifying an amino-acid deletion in nsp2 (Asp268Del) present in multiple samples and other European viruses.

Strain-dependent impact of G and SH deletions provide new insights for live-attenuated HMPV vaccine development

This study evaluates strain-dependent effects of G and SH deletions in HMPV to inform live-attenuated vaccine development, finding that SH-deleted A1/C-85473 virus is attenuated and protective in mice.

Evolution of influenza genome diversity during infection in immunocompetent patients

This study tracks influenza virus diversity over time in immunocompetent patients, finding higher diversity in late-stage mild cases and specific segment differences across clinical groups.

Repurposing of drugs as novel influenza inhibitors from clinical gene expression infection signatures

This paper identifies 35 FDA-approved drugs with antiviral potential against influenza using transcriptomic signatures, validates 31 in vitro, and highlights diltiazem as a promising candidate for Phase II clinical trials.

Quality control implementation for universal characterization of DNA and RNA viruses in clinical respiratory samples using single metagenomic next-generation sequencing workflow

This paper evaluates a single metagenomic next-generation sequencing workflow for detecting DNA and RNA viruses in clinical respiratory samples, showing high accuracy and correlation with PCR results.