Author

S. Constant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 2 Organism:multiple species· 1

Frequent Co-Authors

S. Huang· 3 shared A. Pizzorno· 2 shared B. Boda· 2 shared B. Padey· 2 shared C. Medaglia· 2 shared C. Tapparel· 2 shared F. Stellacci· 2 shared M. Rosa-Calatrava· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

S. Huang

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The triple combination of Remdesivir (GS-441524), Molnupiravir and Ribavirin is highly efficient in inhibiting coronavirus replication in human nasal airway epithelial cell cultures and in a hamster infection model

T. N. D. Do, R. Abdelnabi, B. Boda, S. Constant, J. Neyts, D. Jochmans

This paper evaluates a triple antiviral combination's efficacy against coronavirus in cell cultures and a hamster model, finding enhanced antiviral effects even with suboptimal doses.

bioRxiv · May 14, 2024Microbiology

Development of Broad-spectrum β-cyclodextrins-Based Nanomaterials Against Influenza Viruses

A. C.-A. Zwygart, C. Medaglia, Y. Zhu, E. B. Tarbet, J. B. Westover, C. Fage, D. Le Roy, T. Roger, S. Constant, S. Huang, F. Stellacci, P. J. Silva, C. Tapparel

This study develops CD-SA, a β-cyclodextrin-based nanomaterial that acts as a potent broad-spectrum antiviral against influenza A and B viruses, showing higher efficacy than Oseltamivir in ex vivo and in vivo tests.

bioRxiv · Mar 5, 2024Microbiology

Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro

H. R. Jonsdottir, D. Siegrist, T. Julien, B. Padey, M. Bouveret, O. Terrier, A. Pizzorno, S. Huang, K. Samby, T. Wells, B. Boda, M. Rosa-Calatrava, O. Engler, S. Constant

The paper evaluates antiviral effects of 95 single compounds and 30 combinations, showing that molnupiravir with other drugs inhibits SARS-CoV-2 replication in human nasal epithelium in vitro.

bioRxiv · Jan 10, 2022Microbiology

Drug-free nasal spray as a barrier against SARS-CoV-2 infection: safety and efficacy in human nasal airway epithelia

F. Fais, R. Juskeviciene, V. Francardo, S. Mateos, S. Constant, M. Borelli, I. P. Hohenfeld, T. Meyer

This study tests a nasal spray (AM-301) for safety and efficacy against SARS-CoV-2 infection in human nasal epithelial models, finding it safe and significantly reduces viral titer.

bioRxiv · Jul 12, 2021 · PreprintPharmacology & Toxicology

Pyrimidine biosynthesis inhibitors synergize with nucleoside analogs to block SARS-CoV-2 infection

D. Schultz, R. Johnson, K. Ayyanathan, J. Miller, K. Whig, B. Kamalia, M. Dittmar, S. Weston, H. Hammond, C. Dillen, L. Castellana, J. S. Lee, M. Li, E. M. Lee, S. Constant, , S. Cherry

The paper screens 18,000 drugs for antiviral activity against SARS-CoV-2, identifies synergistic combinations of pyrimidine biosynthesis inhibitors and nucleoside analogs, and validates their efficacy in vitro and in vivo.

bioRxiv · Jun 24, 2021 · PreprintMicrobiology

Characterization and treatment of SARS-CoV-2 in nasal and bronchial human airway epithelia

A. Pizzorno, B. Padey, T. Julien, S. Trouillet-Assant, A. Traversier, E. Errazuriz-Cerda, J. Fouret, J. Dubois, A. Gaymard, X. Lescure, V. Duliere, P. Brun, S. Constant, J. Poissy, B. Lina, , M. Rosa-Calatrava

The paper characterizes SARS-CoV-2 infection in nasal and bronchial airway epithelial models and evaluates the antiviral efficacy of remdesivir and its combination with diltiazem.

bioRxiv · Mar 31, 2020Microbiology

Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo

O. Kocabiyik, V. Cagno, P. Jacob Silva, Y. Zhu, L. Sedano, Y. Bhide, J. Mettier, C. Medaglia, B. Da Costa, S. Constant, S. Huang, L. Kaiser, W. Hinrichs, A. Huckriede, R. Le Goffic, , F. Stellacci

The paper develops non-toxic virucidal macromolecules effective against multiple influenza strains in vitro and in vivo.

bioRxiv · Mar 18, 2020Microbiology