K. Moreau

A cellular basis for the mammalian nocturnal-diurnal switch

The paper identifies a conserved cell-intrinsic signal inversion that enables the transition from nocturnality to diurnality, with mTOR signaling as a central mediator.

Complex regulation of gamma-hemolysin expression impacts S. aureus virulence

This study shows that variations in gamma-hemolysin CB expression in S. aureus isolates correlate with mortality in a rabbit pneumonia model, driven by promoter activity, mRNA stability, and a single SNP affecting translation.

Staphylococcus aureus virulence factor expression matters: input from targeted proteomics shows Panton-Valentine leucocidin impact on mortality

A targeted proteomic method analyzed 44 Staphylococcus aureus virulence factors in 136 pneumonia strains, showing PVL's dose-dependent impact on mortality.

Methylation in NDUFA13 gene promoter disrupts communication between collaborative transcription factors - potential mechanism for onset of breast cancer.

The paper investigates how methylation in the NDUFA13 gene promoter disrupts transcription factor binding, leading to gene downregulation and potentially contributing to breast cancer.

All Staphylococcus aureus bacteraemia strains have the potential to cause infective endocarditis: results of GWAS and experimental animal studies

This study shows that all Staphylococcus aureus bacteraemia strains can cause infective endocarditis, as no genetic differences were found between IE and non-IE strains using GWAS and experimental models.

Cell morphological profiling enables high-throughput screening for PROteolysis TArgeting Chimera (PROTAC) phenotypic signature

This study uses cell morphological profiling to identify phenotypic signatures of PROTACs, revealing mitotoxicity that cannot be predicted from individual components.

Homologous BHLH transcription factors induce distinct deformations of torsionally-stressed DNA: a potential transcription regulation mechanism.

This study shows homologous BHLH transcription factors induce distinct DNA deformations under torsional stress, potentially modulating their transcriptional specificity.

A novel effective live-attenuated human metapneumovirus vaccine candidate produced in the serum-free suspension DuckCelt-T17 cell platform

This study evaluates the use of DuckCelt-T17 avian cells for producing a live-attenuated HMPV vaccine candidate, showing its efficiency and scalability.

Trophic cooperation promotes bacterial survival of Staphylococcus aureus and Pseudomonas aeruginosa

This study shows that acetoin, produced by S. aureus, benefits both S. aureus and P. aeruginosa by providing a carbon source and reducing acetoin toxicity, indicating trophic cooperation in CF lungs.

Sequence-specific dynamics of DNA response elements and their flanking sites regulate the recognition by AP-1 transcription factors

The paper uses molecular dynamics simulations to show that AP-1 factors like Yap1 use sequence-specific DNA dynamics and flanking nucleotides to form stable protein-DNA complexes, influencing gene expression.

NorK, a novel norfloxacin efflux pump in Staphylococcus aureus

The paper identifies NorK, a new norfloxacin efflux pump in Staphylococcus aureus that contributes to resistance and is expressed independently of MgrA regulation.

Coexistence with Pseudomonas aeruginosa alters Staphylococcus aureus transcriptome, antibiotic resistance and internalization into epithelial cells

New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells

The paper identifies two new factors, TTC17 and CCDC157, involved in protein transport through a CRISPRi screen in mammalian cells, showing their roles in Golgi structure and transport carrier fusion.

Genome-wide CRISPR screening identifies new regulators of glycoprotein secretion

This study identifies 50 novel genes regulating glycoprotein secretion through CRISPR screening and validates their role in Golgi apparatus structure.

A dual sRNA in Staphylococcus aureus induces a metabolic switch responding to glucose consumption

The paper identifies RsaI, a CcpA-dependent sRNA in S. aureus that mediates a metabolic switch in response to glucose availability.

Phospholipid flipping facilitates annexin translocation across membranes

This study identifies phospholipid flipping as essential for annexin translocation from the inner to outer leaflet of the plasma membrane, with TMEM16F playing a key role.