Author

B. Lomonte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Fernandez· 2 shared J. M. Gutierrez· 2 shared A. H. Laustsen· 1 shared A. J. Saviola· 1 shared A. Karatt-Vellatt· 1 shared A. Navarro· 1 shared A. Rucavado· 1 shared A. Segura· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersPharmacology & Toxicology

J. Fernandez

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4 papers

Recent·Most cited

A murine experimental model of the unique pulmonary thrombotic effect induced by the venom of the snake Bothrops lanceolatus

A. Rucavado, E. Camacho, T. Escalante, B. Lomonte, J. Fernandez, D. Solano, I. Quiros-Gutierrez, G. Ramirez-Vargas, K. Vargas, I. Arguello, A. Navarro, C. Abarca, A. Segura, J. Florentin, H. Kallel, , J. M. Gutierrez

This paper develops a mouse model of thrombosis induced by Bothrops lanceolatus venom, showing juvenile venom causes more pulmonary thrombi despite similar proteomes to adult venom.

bioRxiv · Jul 3, 2024 · PreprintPharmacology & Toxicology

ASSESSING TARGET SPECIFICITY OF THE SMALL MOLECULE INHIBITOR MARIMASTAT TO SNAKE VENOM TOXINS: A NOVEL APPLICATION OF THERMAL PROTEOME PROFILING

C. F. Smith, C. M. Modahl, D. Ceja-Galindo, K. Y. Larson, S. P. Maroney, L. Bahrabadi, N. P. Brandehoff, B. W. Perry, M. C. McCabe, D. Petras, B. Lomonte, J. J. Calvete, T. A. Castoe, S. P. Mackessy, K. C. Hansen, A. J. Saviola

This study uses Thermal Proteome Profiling and PISA to assess marimastat's specificity against snake venom toxins, identifying its targets and interactions with specific proteoforms.

bioRxiv · Oct 25, 2023Biochemistry

Discovery of a broadly-neutralizing human antibody that can rescue mice challenged with neurotoxin-rich snake venoms

L. Ledsgaard, J. Wade, K. Boddum, I. Oganesyan, J. Harrison, T. P. Jenkins, P. Villar, R. A. Leah, R. Zenobi, J. McCafferty, B. Lomonte, J. M. Gutierrez, A. H. Laustsen, A. Karatt-Vellatt

This paper describes the discovery of a broadly-neutralizing human antibody effective against multiple snake venoms, demonstrating its therapeutic potential in mice.

bioRxiv · Jun 17, 2022 · PreprintBioengineering

Nucleolin internalizes Bothrops asper Lys49 phospholipase A2 forming cell surface amyloid-like assemblies

M. L. Massimino, M. Simonato, B. Spolaore, C. Franchin, G. Arrigoni, O. Marin, L. Monturiol-Gross, J. Fernandez, B. Lomonte, F. Tonello

This paper shows that Bothrops asper Lys49 phospholipase A2 interacts with nucleolin, is internalized by cells via nucleolin, and forms amyloid-like surface assemblies that may drive toxicity.

bioRxiv · Sep 13, 2017Biochemistry