J. Harrison

TBX15 regulates a network of immune response genes in adipose tissue and alters fat mass and depot weight in heterozygous knockout mice

Mutant phenotypes and comprehensive expression analyses reveal roles for CLAVATA in moss vegetative and reproductive development and fertility

This study identifies roles for CLAVATA genes in moss vegetative and reproductive development through promoter analysis and mutant studies.

Wolbachia-infected pharaoh ant colonies have higher egg production, metabolic rate, and worker survival

GDF15 antagonism limits severe heart failure and prevents cardiac cachexia in mice

This study shows that blocking GDF15 reduces severe heart failure and cardiac cachexia in mice by preventing weight loss and slowing disease progression.

Discovery of a broadly-neutralizing human antibody that can rescue mice challenged with neurotoxin-rich snake venoms

This paper describes the discovery of a broadly-neutralizing human antibody effective against multiple snake venoms, demonstrating its therapeutic potential in mice.

Endogenous GDF15 and FGF21 additively alleviate hepatic steatosis and insulin resistance in obese mice.

This study shows that GDF15 and FGF21, secreted by the liver in obese mice, reduce hepatic steatosis and insulin resistance when both are active.

Synergistic Activity of Repurposed Peptide Drug Glatiramer Acetate with Tobramycin Against Cystic Fibrosis Pseudomonas aeruginosa

This study shows that glatiramer acetate enhances tobramycin's effectiveness against Pseudomonas aeruginosa in cystic fibrosis patients by reducing MICs and disrupting bacterial membranes.

A suite of rare microbes interacts with a dominant, heritable, fungal endophyte to influence plant trait expression

The paper manipulates rare and dominant endophytes in plants to show that rare endophytes affect host traits only in the absence of a dominant fungal endophyte, and that interactions between endophytes and pathogens can offset negative effects.

Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics

This study uses HDX-MS and XL-MS to analyze the structural dynamics of the full-length SARS-CoV-2 nsp7:nsp8 complex, revealing conformational flexibility and a different assembly model compared to SARS-CoV.

Intradermal-delivered DNA vaccine provides anamnestic protection in a rhesus macaque SARS-CoV-2 challenge model

This study evaluates an intradermal DNA vaccine against SARS-CoV-2 in rhesus macaques, showing it induces immune responses and provides protection against viral challenge.

Combining amoxicillin and relebactam provides a new therapeutic option for Mycobacterium abscessus infection

This paper shows that combining amoxicillin and relebactam synergistically inhibits Mycobacterium abscessus through non-competitive inhibition of its beta-lactamase, offering a new therapeutic option for infections.

Structural basis of glycerophosphodiester recognition by the Mycobacterium tuberculosis substrate-binding protein UgpB

This study determines the structure of Mtb UgpB bound to GPC and shows it recognizes other glycerophosphodiesters, enhancing understanding of nutrient scavenging in tuberculosis.