A. John

EigenBrain maps cortical molecular architecture from functional, geometric, and structural eigenmodes

The paper shows functional MRI eigenmodes can approximate specific receptor and transporter distributions in the cortex, while structural and geometric eigenmodes cannot, and applies this to detect molecular differences in autism and schizophrenia.

Lestaurtinib's antineoplastic activity converges on JAK/STAT signaling to inhibit advanced forms of therapy resistant ovarian cancer

This study identifies lestaurtinib as a potent inhibitor of ovarian cancer, effective against resistant models, by targeting JAK/STAT signaling and synergizing with standard therapies.

Degradation of Fatty Acid Export Protein1 by Rhomboid-Like Protease11 Contributes to Cold Tolerance in Arabidopsis

The paper shows that RBL11-mediated degradation of FAX1 is critical for cold tolerance in Arabidopsis.

Microclimate buffering varies across forest types during an extreme heat event

The paper examines how forest microclimates buffer against extreme heat events and assesses impacts on organisms and canopy health.

Topography influences diurnal and seasonal microclimate fluctuations in hilly terrain environments of coastal California

The paper examines how topography affects microclimate fluctuations in coastal California, finding elevation and depression features significantly influence temperature variation.

A complete morphological characterization of all life stages of the phorid fly M. scalaris

This study provides a complete morphological characterization of all life stages of M. scalaris using scanning electron microscopy, including a newly observed headless adult phenotype.

Using photographs and deep neural networks to understand flowering phenology and diversity in mountain meadows

This study uses deep learning on crowd-sourced images to quantify flowering species richness in alpine meadows, finding higher richness near the tree line and demonstrating the effectiveness of Mask R-CNN for flower detection.

A network of CLAVATA receptors buffers auxin-dependent meristem maintenance

The paper shows CLV3 signaling interacts with auxin to regulate meristem maintenance and floral primordia formation, with temperature and auxin levels affecting this interaction.

Differential remodelling in small and large murine airways revealed by novel whole lung airway analysis.

The paper uses a new method to analyze whole lung airway sections in mice, revealing differential remodelling in small and large airways after allergen challenge.

Genetic architecture of a body color cline in Drosophila americana

The paper investigates the genetic basis of a body color cline in Drosophila americana, finding that while some alleles resemble those of its sister species, they are unlikely to drive the cline due to their rarity and complexity.

Horseshoe crab genomes reveal the evolutionary fates of genes and microRNAs after three rounds (3R) of whole genome duplication

Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue

The paper examines gene expression and protein localization of potential SARS-CoV-2 receptors in human airway epithelial cells and lung tissue, finding low ACE2 expression and confirming other candidate receptors.

Structural basis of substrate recognition and catalysis by fucosyltransferase 8

This study determines the structural basis of substrate recognition and catalysis by FUT8 through crystal structures and simulations, revealing conformational changes and dimerization roles in substrate binding.

Trefoil factors share a lectin activity that defines their role in mucus

This study identifies trefoil factors as divalent lectins that bind GlcNAc--1,4-Gal disaccharides, contributing to mucus viscoelasticity through non-covalent glycoprotein cross-linking.

POFUT2-mediated O-glycosylation of MIC2 is dispensable for Toxoplasma gondii tachyzoites

This study shows that O-glycosylation of MIC2 by TgPOFUT2 is not essential for Toxoplasma gondii tachyzoite infectivity and plaque formation.