Author

B. Preti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:deep learning· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. Lochner· 3 shared B. Frenguelli· 2 shared C. A. Reynolds· 2 shared G. Deganutti· 2 shared G. Ladds· 2 shared K. Barkan· 2 shared M. Leuenberger· 2 shared M. Wall· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPharmacology & Toxicology

M. Lochner

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Species-specific effects of cation channel TRPM4 small-molecule inhibitors

P. Arullampalam, B. Preti, D. Ross-Kaschitza, M. Lochner, J.-S. Rougier, H. Abriel

This study compares the effects of TRPM4 inhibitors on human and mouse TRPM4 channels, revealing species-specific responses and highlighting the need for in vivo validation.

bioRxiv · Jun 1, 2021Pharmacology & Toxicology

Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor

G. Deganutti, K. Barkan, B. Preti, M. Leuenberger, M. Wall, B. Frenguelli, M. Lochner, G. Ladds, C. A. Reynolds

The paper uses molecular dynamics simulations and mutagenesis to study agonist binding to the A1 receptor, identifying new residues and binding modes of CPA-related ligands.

bioRxiv · Oct 22, 2020Pharmacology & Toxicology

Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression

M. Wall, E. Hill, R. Huckstepp, K. Barkan, G. Deganutti, M. Leuenberger, B. Preti, I. Winfield, S. Carvalho, A. Suchankova, H. Wei, D. Safitri, X. Huang, W. Imlach, C. La Mache, , B. Frenguelli

The paper identifies BnOCPA as an A1R agonist that selectively activates Gαob, providing analgesia without cardiorespiratory depression.

bioRxiv · Apr 4, 2020Physiology