Glucocorticoid intermittence coordinates rescue of energy and mass in aging-related sarcopenia through the myocyte-autonomous PGC1alpha-Lipin1 transactivation
A. D. Prabakaran, K. McFarland, K. Miz, H. B. Durumutla, F. E. A. Soussi, K. Piczer, H. Latimer, C. Werbrich, N. S. Blair, D. P. Millay, B. Prideaux, B. N. Finck, M. Quattrocelli
This study shows that intermittent glucocorticoid treatment rescues both energy and mass in aging-related sarcopenia via the PGC1alpha-Lipin1 pathway in muscle cells.
bioRxiv · Oct 16, 2023 · PreprintPhysiology