Author

S. Subbian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Research Focus:cell type annotation· 5 Organism:human· 5 Assay:bulk RNA-seq· 4 Assay:proteomics· 4 Organism:rat· 4 Research Focus:differential expression· 3

Frequent Co-Authors

A. Kolloli· 4 shared R. Kumar· 4 shared S. Tyagi· 3 shared L. Shi· 2 shared S. Ramasamy· 2 shared A. Beaulieu· 1 shared A. K. Choudhary· 1 shared A. K. Ojha· 1 shared

Activity by Year

2019-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersImmunology

A. Kolloli

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Fatty acid metabolism in neutrophils promotes lung damage and bacterial replication during tuberculosis.

B. B. Mishra, P. Sankar, R. B. Ramos, J. Corro, M. Saqib, T. N. Nafiz, G. Bhargavi, A. K. Ojha, Y. Cai, S. Subbian

This study shows that fatty acid metabolism in neutrophils worsens lung damage and bacterial replication in tuberculosis by promoting inflammation and neutrophil recruitment.

bioRxiv · Oct 25, 2023Immunology

Cryptococcosis, tuberculosis, and a kidney cancer fail to fit the atherosclerosis paradigm for foam cell lipid content

V. Guerrini, B. Prideaux, R. Khan, S. Subbian, Y. Wang, E. Sadimin, S. Pawar, R. Ukey, E. A. Singer, C. Xue, M. L. Gennaro

The paper investigates lipid accumulation in foam cells across different diseases and finds that lipid content varies by disease and microenvironment.

bioRxiv · Jun 8, 2023Immunology

Broad-Spectrum Heavily Mutated Monoclonal Antibody Isolated from COVID-19 Convalescent Vaccinee with Capacity to Neutralize SARS-CoV2 Variants Ranging from B.1 to BQ.1.1

A. K. Choudhary, D. Calianese, W. Honnen, A. Kolloli, R. J. Dikdan, D. Jaijyan, G. Song, T. Capozzola, V. Akkaraju, A. Mattappallil, A. Rosania, S. Khan, M. Lerman, N. Afzal, S. Subbian, , A. Pinter

The paper isolates and characterizes Acovimab, a broadly neutralizing monoclonal antibody against SARS-CoV-2 variants, showing potent neutralization against most variants except XBB.1.5 and synergistic activity with Sotrovimab.

bioRxiv · May 4, 2023 · PreprintImmunology

Interferon epsilon restricts Zika virus infection in the female reproductive tract

C. Xu, A. Wang, L. Ebraham, L. Sullivan, C. Tasker, V. Pizutelli, J. Couret, C. Hernandez, P. Q. Deb, L. Fritzky, S. Subbian, N. Gao, Y. Lo, M. Salvatore, A. Rivera, , T. L. Chang

This study shows that IFNε protects against vaginal ZIKV infection in mice by maintaining epithelial integrity and is effective even without IFNAR1 signaling.

bioRxiv · Apr 6, 2023Immunology

A SARS-CoV-2 vaccine designed for manufacturability results in unexpected potency and non-waning humoral response

E. Campbell, J. Dobkin, L. Osorio, S. Ramasamy, R. Kumar, D. B. SantAngelo, S. Subbian, L. K. Denzin, S. Anderson

This paper describes a SARS-CoV-2 vaccine, MT-001, that provides durable, broad, and potent immunity without waning or requiring boosting.

bioRxiv · Feb 6, 2023Immunology

Imaging Architecture of Granulomas Induced by Mycobacterium tuberculosis Infections with Single-Molecule FISH

R. Kumar, A. Kolloli, S. Subbian, D. Kaushal, L. Shi, S. Tyagi

The paper develops a method to image mRNA and protein markers in tuberculosis granulomas using smFISH derivatives, enabling classification of immune cell subtypes and their spatial distribution.

bioRxiv · Feb 2, 2023 · PreprintImmunology

Glutamine is required for M1-like polarization in response to Mycobacterium tuberculosis infection

L. Shi, Q. Jiang, Y. Qiu, I. J. Kurland, K. Drlica, S. Subbian, S. Tyagi

This study identifies glutamine as essential for M1-like macrophage polarization during Mycobacterium tuberculosis infection through metabolic reprogramming involving the TCA cycle and biosynthesis of signaling molecules and antimicrobial metabolites.

bioRxiv · Jan 11, 2022 · PreprintImmunology

Comprehensive analysis of disease pathology in immunocompetent and immunocompromised hamster models of SARS-CoV-2 infection

S. Ramasamy, A. Kolloli, R. Kumar, S. Hussain, P. Soteropoulos, T. Chang, S. Subbian

This study compares SARS-CoV-2 infection outcomes in immunocompetent and immunocompromised hamsters, finding that histopathological changes better predict disease severity than viral load or antibody levels.

bioRxiv · Jan 7, 2022 · PreprintPathology

Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology

A. Kolloli, R. Kumar, P. Singh, A. Narang, G. Kaplan, A. Sigal, S. Subbian

This study shows that aggregated Mycobacterium tuberculosis causes more severe lung disease in rabbits by increasing bacterial growth and inflammation compared to single-cell infections.

bioRxiv · May 19, 2021Microbiology

Dual RNA-seq provides insight into the biology of the neglected intracellular human pathogen Orientia tsutsugamushi

B. Mika-Gospodorz, S. Giengkam, A. Westermann, J. Wongsantichon, W. B. Kion-Crosby, S. Chuenklin, L. C. Wang, P. Sunyakumthorn, R. Sobota, S. Subbian, J. Vogel, L. Barquist, J. Salje

The paper uses dual RNA-seq to study the transcriptional architecture and host-pathogen interactions of Orientia tsutsugamushi, identifying antisense regulation and strain-specific immune responses.

bioRxiv · Oct 29, 2019Microbiology