Author

B. Pruitt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Assay:imaging· 5 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2

Frequent Co-Authors

G. Pardon· 4 shared E. A. Castillo· 3 shared A. S. Vander Roest· 2 shared A. C.-Y. Chang· 1 shared A. Dawood· 1 shared A. Jhingran· 1 shared A. K. Denisin· 1 shared C. A. Blair· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersBioengineering

G. Pardon

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Spatial Patterning of Laminin and N-Cadherin for Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs)

K. V. Lane, L. P. Dow, E. A. Castillo, R. Boros, S. D. Feinstein, G. Pardon, B. Pruitt

This study develops a dual-protein patterning method to enhance hiPSC-CM structure and function by incorporating N-cadherin, but finds it insufficient to fully replicate cell-cell contact effects.

bioRxiv · Sep 29, 2023 · PreprintBioengineering

Insights into single hiPSC-derived cardiomyocyte phenotypes and maturation using ConTraX, an efficient pipeline for tracking contractile dynamics

G. Pardon, H. Lewis, A. S. Vander Roest, E. A. Castillo, R. E. Wilson, A. K. Denisin, C. A. Blair, F. Birnbaum, C. Holbrook, K. Koleckar, A. C.-Y. Chang, H. M. Blau, B. Pruitt

The paper develops ConTraX, a pipeline to track contractile dynamics in single hiPSC-CMs, revealing maturation patterns through high-dimensional clustering.

bioRxiv · Mar 18, 2021 · PreprintBioengineering

Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super-relaxed state: multiscale measurements and computational modeling

A. S. Vander Roest, C. Liu, M. M. Morck, K. B. Kooiker, G. Jung, D. Song, A. Dawood, A. Jhingran, G. Pardon, S. Ranjbarvaziri, G. Fajardo, M. Zhao, K. S. Campbell, B. Pruitt, J. A. Spudich, , D. Bernstein

This study investigates the P710R mutation in β-cardiac myosin, showing it causes hypercontractility by disrupting the super-relaxed state, using multiscale experiments and modeling.

bioRxiv · Nov 10, 2020 · PreprintBiophysics

An Easy-to-Fabricate Cell Stretcher Reveals Density-Dependent Mechanical Regulation of Collective Cell Movements in Epithelia

K. C. Hart, J. Y. Sim, M. A. Hopcroft, D. J. Cohen, J. Tan, W. J. Nelson, B. Pruitt

The paper describes a low-cost cell stretcher device that reveals density-dependent mechanical regulation of collective cell movements in epithelia.

bioRxiv · Aug 24, 2020Bioengineering

A benchmarking model for validation and standardization of traction force microscopy analysis tools

G. Pardon, E. A. Castillo, B. Pruitt

The paper develops a virtual model to benchmark traction force microscopy analysis tools by simulating cell contraction and testing algorithm accuracy.

bioRxiv · Aug 14, 2020 · PreprintBiophysics