D. Bernstein

YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes

This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.

Structure of the Thin Filament in Human iPSC-derived Cardiomyocytes and its Response to Heart Disease

This study uses cryo-ET to analyze the structure of thin filaments in human iPSC-derived cardiomyocytes and how they change with disease-related perturbations.

Blood flow modeling reveals improved collateral artery performance during mammalian heart regeneration

This study uses computational modeling to show neonatal collateral arteries are more effective than adult ones in restoring blood flow during heart regeneration.

Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super-relaxed state: multiscale measurements and computational modeling

This study investigates the P710R mutation in β-cardiac myosin, showing it causes hypercontractility by disrupting the super-relaxed state, using multiscale experiments and modeling.

Dynamic changes in natural killer cell subset frequencies in the absence of cytomegalovirus infection

This study examines NK cell subset frequencies in CMV-seronegative adolescents after a CMV gB vaccine, finding dynamic fluctuations in FcR{gamma}neg NK cells independent of vaccination or CMV infection.

Hypertrophic cardiomyopathy mutations at the folded-back sequestered β-cardiac myosin S1-S2 and S1-S1 interfaces release sequestered heads and increase myosin enzymatic activity

This study shows HCM mutations at specific myosin interfaces increase accessible heads and myosin activity, contributing to hypercontractility.