PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression
C. Schmidt, S. Cohen, B. L. Gudenas, S. Husain, A. Carlson, S. Westelman, L. Wang, J. J. Phillips, P. A. Northcott, W. A. Weiss, B. Schwer
This study shows PRDM6 represses chromatin accessibility and alters gene expression in neuroepithelial stem cells, promoting medulloblastoma but not sufficient to drive Group 4 medulloblastoma alone.
bioRxiv · Aug 29, 2023 · PreprintCancer Biology