A. Carlson

PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression

This study shows PRDM6 represses chromatin accessibility and alters gene expression in neuroepithelial stem cells, promoting medulloblastoma but not sufficient to drive Group 4 medulloblastoma alone.

Stability of a biomembrane tube covered with proteins

The paper analyzes the stability of a biomembrane tube covered with proteins using a combination of linear stability analysis, hydrodynamic calculations, and a Helfrich-like model, showing that both long and short-wavelength perturbations can destabilize the tube.

Architecture of the chikungunya virus replication organelle

This study uses cryo-electron tomography to reveal the architecture of CHIKV spherules and presents a mathematical model explaining their membrane remodeling.

Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence

The paper shows that quiescent human keratinocyte monolayers undergo stress amplification and fluidization upon serum stimulation, linking mechanical stress to tissue motility.

Divalent ligand-monovalent molecule binding

The paper derives a general mathematical model for divalent ligand-monovalent molecule binding at any concentration ratio, showing the intermediate complex concentration is governed by a cubic equation.

Protein Crowding Mediates Membrane Remodeling in Upstream ESCRT-induced Formation of Intraluminal Vesicles

This study shows upstream ESCRTs mediate membrane deformation and ILV formation through crowding and altering bending rigidity, without requiring ATP.

Membrane Shape Remodeling by Protein Crowding

This study presents a minimal model showing that steric repulsion between membrane-associated proteins induces spontaneous curvature, determining energy-minimizing membrane shapes observed in experiments.

Protein diffusion on membrane domes, tubes and pearling structures

The paper studies protein diffusion on complex membrane shapes and finds a quadratic relationship between diffusive half time and membrane curvature.

Rapid growth and fusion of protocells in surface-adhered membrane networks

This study shows that moderate temperature increases promote the rapid growth and fusion of protocells formed from lipid networks on solid surfaces, enabling RNA encapsulation and redistribution.

Artificial Microbiome-Selection to Engineer Microbiomes That Confer Salt-Tolerance to Plants

This paper develops an artificial microbiome-selection method to engineer salt-tolerant microbiomes for the plant Brachypodium distachyon, showing significant fitness improvements under sodium- and aluminum-sulfate stress.

Estimating relative CWD susceptibility and disease progression in farmed whitetail deer with rare PRNP alleles

The paper assesses CWD susceptibility and progression in farmed whitetail deer with rare PRNP alleles by analyzing infection status and disease stage in over 2100 deer.

A nanotube-mediated path to protocell formation

This paper demonstrates a spontaneous pathway for forming protocell-like structures from lipid deposits on solid surfaces through nanotube-mediated transformations.