L. Brown

Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer

This study shows that integrin conformation-dependent neutrophil slowing in pre-metastatic lungs obstructs capillaries and may contribute to immunosuppression in breast cancer.

Protease-mediated degradation of the master transcription factor controls quorum sensing-state transitions in Vibrio

This study identifies PTSP as a ligand that induces proteolytic degradation of SmcR, controlling quorum sensing state transitions in Vibrio species.

Phylogenomics, biogeography, and trait evolution of the Boletaceae (Boletales, Agaricomycetes, Basidiomycota)

This study presents a genome-wide phylogenetic analysis of Boletaceae fungi, revealing their evolutionary history, biogeography, and trait evolution.

WCRC-25: A novel luminal Invasive Lobular Carcinoma cell line model

The paper introduces a new invasive lobular carcinoma cell line, WCRC-25, and demonstrates its molecular features and therapeutic response to PI3K/AKT inhibition.

Assessing the global prevalence of wild birds in trade

This paper quantifies global bird trade prevalence using seven datasets, identifying species at risk and informing conservation strategies.

Anti-Viral and Anti-Inflammatory Therapeutic Effect of RAGE-Ig Protein Against Multiple SARS-CoV-2 Variants of Concern Demonstrated in K18-hACE2 Mouse and Syrian Golden Hamster Models

This study shows RAGE-Ig reduces viral replication and inflammation in multiple SARS-CoV-2 variants using animal models and human cells.

Structural foundations of potassium selectivity in channelrhodopsins

This study identifies structural motifs in kalium channelrhodopsins (KCRs) responsible for their K+ selectivity, showing that specific mutations convert Na+ selectivity to K+ selectivity.

Consistent predictors of microbial community composition across scales in grasslands reveal low context-dependency

The paper identifies consistent predictors of microbial community composition across grassland scales, finding low context-dependency and predictable variation linked to productivity.

3D matrix adhesion composition facilitates nuclear force coupling to drive invasive cell migration

This study identifies a 3D matrix adhesion complex involving β-PIX and Myo18A that drives invasive cell migration by coupling nuclear force transmission to protrusion dynamics.

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

The paper identifies FOXA1 reprogramming in NEPC and shows its role in maintaining NE lineage features through epigenomic profiling.

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

This study identifies two distinct subtypes of neuroendocrine prostate cancer based on neuronal transcription factors and highlights their epigenetic convergence and therapeutic implications.

Conductance mechanisms of rapidly desensitizing cation channelrhodopsins from cryptophyte algae

The paper identifies 19 new BCCR proteins from cryptophyte algae, revealing distinct conductance mechanisms and rapid desensitization in two subfamilies through electrophysiology and spectroscopy.

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

This paper completes the metabolic pathway for bile acid dehydroxylation by the gut microbiome and demonstrates its heterologous expression in a non-producing commensal.

Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespan

This study examines age-related changes in nasal mucosal immune composition and function, finding reduced granulocytes and T cells in young children and older adults, and links pneumococcal colonization to inflammation.

Listeria monocytogenes virulence factors are secreted in biologically active Extracellular Vesicles

This study shows Listeria monocytogenes secretes biologically active extracellular vesicles containing virulence factors like LLO and PI-PLC, which contribute to cytotoxicity in macrophages.