Author

M. Tosolini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2

Frequent Co-Authors

A. Carrier· 2 shared A. Hedley· 2 shared A. Kilbey· 2 shared A. V. Villard· 2 shared B. Thibault· 2 shared C. Basset· 2 shared C. Cayron· 2 shared G. Reyes-Castellanos· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPathology

A. Carrier

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

IL-27 maintains cytotoxic Ly6C+ gamma delta T cells that arise from immature precursors

R. Wiesheu, S. C. Edwards, A. Hedley, M. Tosolini, M. G. F. Fares da Silva, N. Sumaria, Y. Optaczy, D. G. Hill, A. J. Hayes, J. Hay, A. Kilbey, A. M. Michie, G. Graham, A. Manoharan, C. Halsey, , S. B. Coffelt

The paper identifies immature and mature subsets of IFNγ-producing γδ T cells, showing IL-27 supports cytotoxic function in mature cells but not immature ones.

bioRxiv · Oct 26, 2023Immunology

Meat enriched-diet and inflammation promote PI3Kα-dependent pancreatic cell plasticity that limit tissue regeneration.

C. Cayron, D. Bozoglou, A. V. Villard, G. Reyes-Castellanos, N. Therville, R. Baer, S. Arcucci, N. Naud, M. Tosolini, F. Pont, D. Ferreira Da Mota, F. Gueraud, C. Basset, A. Carrier, F. Pierre, , J. Guillermet-Guibert

This study shows that meat-enriched diets and inflammation promote pancreatic cell plasticity via PI3Kα, which limits tissue regeneration and increases cancer risk.

bioRxiv · Aug 22, 2023 · PreprintPathology

Pancreatic Cancer Intrinsic PI3Kα Activity accelerates Metastasis and rewires Macrophage Component

B. Thibault, F. Ramos-Delgado, E. Pons-Tostivint, N. Therville, C. Cintas, S. Arcucci, S. Cassant-Sourdy, G. Reyes-Castellanos, M. Tosolini, A. V. Villard, C. Cayron, R. Baer, J. Bertrand-Michel, D. Payen, H. Yan, , J. Guillermet-Guibert

This paper identifies PI3K pathway activation as a driver of metastatic progression in pancreatic cancer and shows that targeting PI3K can delay macro-metastatic evolution.

bioRxiv · Sep 23, 2020Cancer Biology

Ly6C defines a subset of memory-like CD27+ γδ T cells with inducible cancer-killing function

R. Wiesheu, S. C. Edwards, A. Hedley, K. Kirschner, M. Tosolini, J.-J. Fournie, A. Kilbey, S.-J. Remak, C. Miller, K. Blyth, S. B. Coffelt

The paper identifies two subsets of CD27+ γδ T cells in mice, distinguished by Ly6C expression, with one subset showing memory-like properties and cancer-killing potential.

bioRxiv · Sep 8, 2020 · PreprintImmunology

Colon-specific immune microenvironment regulates cancer progression versus rejection

G. Trimaglio, A.-F. Tilkin-Mariame, V. Feliu, F. Lauzeral-Vizcaino, M. Tosolini, C. Valle, M. Ayyoub, O. Neyrolles, N. Vergnolle, Y. Rombouts, C. Devaud

This study shows that the colon microenvironment influences whether colorectal tumors progress or are rejected, with distinct immune signatures in each outcome.

bioRxiv · Jan 2, 2020Cancer Biology