Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma
D. Wang, C. Ritz, A. Pierce, B. Brunt, Y. Luo, N. Dahl, S. Venkataraman, E. Danis, K. Kus, M. Mazan, T. Rzymski, B. Veo, R. Vibhakar
This study identifies CDK8 as a critical dependence in MYC-driven medulloblastoma, showing its role in regulating transcription and translation through mechanisms involving ribosome biogenesis and 4EBP1 phosphorylation.
bioRxiv · Mar 8, 2024 · PreprintCancer Biology