Author

B. Brunt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Green· 2 shared A. Pierce· 2 shared D. Wang· 2 shared N. Dahl· 2 shared R. Vibhakar· 2 shared S. Venkataraman· 2 shared A. Donson· 1 shared A. M. Pierce· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

A. Green

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Targeting Diffuse Midline Glioma with a novel anti-CD99 Antibody

I. Balakrishnan, K. Madhavan, A. M. Pierce, J. A. Michlin, B. Brunt, S. L. Chetty, D. Wang, J. DeSisto, Z. Nuss, N. Davidson, A. Donson, K. Jones, S. S. Mitra, A. Green, N. Dahl, , S. Venkataraman

This paper identifies CD99 as a therapeutic target in K27M+DMGs, showing that a novel anti-CD99 antibody reduces tumor growth and enhances radiation efficacy in preclinical models.

bioRxiv · Mar 19, 2024 · PreprintCancer Biology

Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma

D. Wang, C. Ritz, A. Pierce, B. Brunt, Y. Luo, N. Dahl, S. Venkataraman, E. Danis, K. Kus, M. Mazan, T. Rzymski, B. Veo, R. Vibhakar

This study identifies CDK8 as a critical dependence in MYC-driven medulloblastoma, showing its role in regulating transcription and translation through mechanisms involving ribosome biogenesis and 4EBP1 phosphorylation.

bioRxiv · Mar 8, 2024 · PreprintCancer Biology

MRI-Guided Focused Ultrasound Blood-Brain Barrier Opening Increases Drug Delivery and Efficacy in a Diffuse Midline Glioma Mouse Model

P. J. Martinez, G. Nault, J. Steiner, M. F. Wempe, A. Pierce, B. Brunt, M. Slade, A. Mongin, J. J. Song, K.-H. Song, N. Ellens, N. Serkova, A. Green, M. A. Borden

MRI-guided focused ultrasound with microbubbles increases panobinostat delivery and efficacy in a diffuse midline glioma mouse model, reducing tumor volume and improving survival.

bioRxiv · Apr 5, 2023Bioengineering