K. Kus

Mitochondria-targeted hydrogen sulfide donor reduces atherogenesis by reprogramming macrophages and increasing UCP1 expression in vascular smooth muscle cells

This study shows that the mitochondrial H2S donor AP39 reduces atherosclerosis by reprogramming macrophages and increasing UCP1 in vascular smooth muscle cells.

Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma

This study identifies CDK8 as a critical dependence in MYC-driven medulloblastoma, showing its role in regulating transcription and translation through mechanisms involving ribosome biogenesis and 4EBP1 phosphorylation.

3D culture of pancreatic cancer cells in vitro recapitulates an aberrant mitochondrial oxidative phosphorylation genotype observed in vivo

This study shows that 3D cultures of pancreatic cancer cells better replicate the mitochondrial oxidative phosphorylation genotype seen in vivo compared to 2D cultures.

Thermodynamic analysis of Zα domain-nucleic acid interactions

The paper analyzes the thermodynamics of Z domain-nucleic acid interactions to understand binding mechanisms and differences between Z domains from different proteins.

Enrichment of Zα domains at cytoplasmic stress granules is due to their innate ability to bind nucleic acids

The paper shows that Z domain-containing proteins localize to stress granules due to their nucleic acid binding ability, as demonstrated through protein interactions and stress granule enrichment experiments.