B. Geiger

Molecular mechanisms underlying the modulation of T-cell proliferation and cytotoxicity by immobilized CCL21 and ICAM1

This study investigates how a synthetic immune niche modulates T-cell proliferation and cytotoxicity, finding that these properties are negatively correlated and differentially regulated by activation mode.

Multi-site assessment of reproducibility in high-content live cell imaging data

This study assesses reproducibility in high-content live cell imaging data across multiple sites and identifies sources of variability, showing that batch correction improves meta-analysis of perturbation experiments.

A network of mixed actin polarity in the leading edge of spreading cells

This study uses cryo-ET to reveal three distinct actin sub-domains in lamellipodia, including filaments with barbed ends pointing toward the cell center.

How talin allosterically activates vinculin

This study identifies an allosteric network in vinculin regulated by talin, showing how force and binding dynamics control focal adhesion formation.

Modulating the proliferative and cytotoxic properties of human TIL by a synthetic immune niche of immobilized CCL21 and ICAM1

This study shows that a synthetic immune niche with CCL21 and ICAM1 enhances TIL expansion and cytotoxicity in vitro and in vivo.

Deciphering the involvement of the Hippo pathway co-regulators, YAP/TAZ in invadopodia formation and matrix degradation

This study investigates the role of YAP/TAZ in invadopodia formation and matrix degradation in cancer cells, finding they suppress invadopodia formation and enhance matrix degradation when inhibited.

Chiral growth of adherent filopodia

This study identifies myosin-X and DAAM1 as key factors promoting chiral growth in adherent filopodia, revealing how actin dynamics drive left-right asymmetry in cellular protrusions.

Rock inhibitors target SRSF2 leukemia by disrupting cell mitosis and nuclear morphology

This study identifies ROCK inhibitors as effective targeting agents for SRSF2 mutant leukemia by disrupting mitosis and nuclear morphology in vitro and in xenograft models.

The Serine Protease HtrA2 mediates radiation-induced senescence in cancer cells

This study identifies HtrA2 as a mediator of radiation-induced senescence in cancer cells, showing its role in proliferation arrest and vimentin filament reorganization.

Differential cellular responses to adhesive interactions with galectin-8 and fibronectin coated substrates

This study compares how HeLa-JW cells respond to fibronectin, galectin-8, and their mixtures, revealing distinct effects on cell spreading, focal adhesions, and filopodia formation.

R51Q SNX10 induces osteopetrosis by promoting uncontrolled fusion of monocytes to form giant, non-functional osteoclasts

This study identifies R51Q SNX10 mutation as a cause of osteopetrosis by promoting abnormal monocyte fusion into non-functional giant osteoclasts.

Cross-talk between the receptor tyrosine kinases AXL and ERBB3 regulates invadopodia formation in melanoma cells

This study identifies AXL and ERBB3 cross-talk as regulators of invadopodia formation in melanoma cells, showing AXL's dual role and ERBB3's compensatory activation upon AXL suppression.

Conformational states during vinculin unlocking differentially regulate focal adhesion properties

This study investigates how vinculin's conformational changes affect focal adhesion properties by analyzing the transition from closed to open states.

Dual role of E-cadherin in the regulation of invasive collective migration of mammary carcinoma cells

This study shows that moderate E-cadherin levels in 4T1 cells promote collective migration and metastasis, while reduced levels enhance migration rate and suppress metastases.