Cancer BiologyCancer DiscoveryPeer-reviewed
ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers
P. Mu, Y. Xu, Z. Wang…·T. Wang
This study shows ZNF397 loss leads to TET2-driven epigenetic changes, lineage plasticity, and resistance to AR-targeted therapies in AR-dependent cancers, with TET2 inhibitors reversing resistance.
DOI 10.1158/2159-8290.cd-23-0539