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Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cells

This study identifies branched chain α-ketoacids (BCKAs) as novel signaling metabolites that activate HIF1α signaling in normoxia and modulate vascular smooth muscle cell function in pulmonary vascular disease.

SASH1 impairs melanin synthesis and metastasis by down-regulating the TGF-β signaling pathway

This study shows SASH1 reduces melanin synthesis and metastasis by suppressing TGF-β1 signaling through regulation of THBS1 in melanocytes.

Characterizing interactions of ER resident proteins in situ through the YST-PPI method

The paper introduces YST-PPI, a method to study ER resident protein interactions in situ, identifies 74 protein pairs, and highlights Lhs1p's role in regulating these interactions.

Location of phosphorylation sites within long polypeptide chains by binder-assisted nanopore detection

This study uses nanopore technology with binders to detect and map phosphorylation sites in long polypeptides, advancing nanopore proteomics.

Cyclocarya paliurus polysaccharides improve high fat diet-fed mice lipid dysmetabolism through gut microbiota

This study shows Cyclocarya paliurus polysaccharides reduce obesity and lipid dysmetabolism in high fat diet-fed mice by modulating gut microbiota.

Non-invasive optoacoustic imaging visualizes exercise-induced dermal revascularization in obese mice

The paper uses optoacoustic imaging to monitor microvascular changes in obese mice during exercise, showing improved vascular density and oxygenation in adipose tissues.

Exo70 promotes herpesvirus secretory vesicle tethering and virion release in an exocyst complex-dependent manner

This study identifies Exo70's role in herpesvirus secretory vesicle tethering and virion release via the exocyst complex, showing ES2 inhibits herpesvirus infection.

Click-free imaging of carbohydrate trafficking in live cells using an azido photothermal probe

This paper demonstrates click-free imaging of carbohydrate trafficking in live cells using azido photothermal probes, revealing trehalose recycling and protein interactions in mycobacteria and other organisms.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

The change of lymphocyte subsets and inflammatory cytokine in BK viruria

This study compares cytokine levels in urine and blood of kidney transplant recipients with and without BK viruria, finding higher inflammatory cytokines in BK-positive patients.

ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers

This study shows ZNF397 loss leads to TET2-driven epigenetic changes, lineage plasticity, and resistance to AR-targeted therapies in AR-dependent cancers, with TET2 inhibitors reversing resistance.

Local two-photon excitation reveals the mechanism of mitochondrial Ca2+ release

This study uses two-photon excitation to reveal that mitochondrial Ca2+ release is driven by ATP synthesis and the electron transport chain, not Ca2+ entry.

Water and chloride as allosteric inhibitors in WNK kinase osmosensing

This study investigates how water and chloride regulate WNK kinase activity through structural and mutagenesis analyses of WNK1 and WNK3.

Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β; pro-inflammatory signaling

This study shows that clonal hematopoiesis driven by TET2 mutations interacts with inflammatory signals like PTX3/IL-1β to promote colitis and leukemia through a gut-bone marrow axis.

Inflammation plays a critical role in damage to the bronchiolar epithelium induced by Trueperella pyogenes in vitro and in vivo

This study investigates T. pyogenes-induced damage to bronchiolar epithelium in vitro and in vivo, identifying inflammatory pathways and potential therapeutic targets.

Design, construction and optimization of formaldehyde growth biosensors with broad application in Biotechnology

This paper designs and optimizes formaldehyde-detecting E. coli biosensors with broad applications in biotechnology and environmental monitoring.

HSP90 inhibitor NVP-HSP990 alleviates rotavirus infection

This study shows that NVP-HSP990, a HSP90 inhibitor, effectively reduces rotavirus infection in vitro and in mice by inhibiting replication and alleviating intestinal damage.

A mutation-mediated host shift drives Avian paramyxovirus type 1 evolution

This study identifies mutations in the P protein of Avian paramyxovirus type 1 that drive host shift from chickens to pigeons through enhanced degradation of LSm14A.

CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesis

This study compares the tumorigenic potential of MOLT4 and JURKAT T-ALL cell lines, finding that CCR9 overexpression enhances cholesterol biosynthesis and promotes T-ALL progression.

Interleukin-16/STAT6 recruits CBP/p300 to upregulate TIMP-3 and promote atherosclerotic plaque stability

This study shows IL-16 promotes atherosclerotic plaque stability by upregulating TIMP-3 through STAT6 and CBP/p300 recruitment.

Carotenoid assembly regulates quinone diffusion and the Roseiflexus castenholzii reaction center-light harvesting complex architecture

This study investigates how carotenoid assembly affects quinone diffusion and the structure of the reaction center-light harvesting complex in Roseiflexus castenholzii.

Video-rate Mid-infrared Photothermal Imaging by Single Pulse Photothermal Detection per Pixel

This paper introduces a single pulse photothermal microscope for video-rate mid-infrared imaging, enabling observation of lipid dynamics and mapping fat storage in living systems.

Proliferating cell nuclear antigen involves in temperature stress tolerance of Ulva prolifera

This study identifies PCNA's role in temperature stress tolerance of Ulva prolifera, showing its interaction with CyclinA and regulation by miR-2916 through the MAPK pathway.

A Borrelia burgdorferi LptD Homolog Facilitates Flipping of Surface Lipoproteins Through the Spirochetal Outer Membrane

This study identifies BB0838 as essential for surface lipoprotein translocation in Borrelia burgdorferi, showing it facilitates flipping of lipoproteins through the outer membrane.

Inducible CRISPRi-based operon silencing and selective in trans gene complementation in Borrelia burgdorferi

This paper develops an inducible CRISPRi system for gene repression in Borrelia burgdorferi and demonstrates in trans complementation to study gene function.

The Cation/H+ exchanger OsCAX2 is involved in cadmium tolerance and accumulation through vacuolar sequestration in rice

This study identifies OsCAX2 as a key gene for cadmium tolerance and accumulation in rice by promoting vacuolar sequestration, reducing grain cadmium levels by over 70%.

Engineering CAR-NK cells targeting CD33 with concomitant extracellular secretion of anti CD16 antibody revealed superior antitumor effects toward myeloid leukemia

This study develops bifunctional CAR-NK cells targeting CD33 with anti-CD16 antibody secretion, showing improved antitumor effects against AML in vitro and in vivo.

Mesenchymal stem cell suppresses the efficacy of CAR-T toward killing lymphoma cells by modulating the microenvironment through stanniocalcin-1

This study shows that mesenchymal stem cells (MSCs) reduce CAR-T cell effectiveness against lymphoma by altering the microenvironment via stanniocalcin-1.

An R-R-type MYB transcription factor promotes nonclimacteric pepper fruit ripening pigmentation

This study identifies a MYB transcription factor that regulates capsanthin biosynthesis in nonclimacteric pepper fruit, showing its role in carotenoid accumulation and interaction with abscisic acid.

Tomographic-encoded multiphoton (TEMP) microscopy

The paper introduces TEMP microscopy, a novel tomographic technique for fast volumetric imaging with high resolution and reduced photodamage, demonstrating its effectiveness on scattering tissues and mouse brain slices.