ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers
P. Mu, Y. Xu, Z. Wang, M. Sjostrom, S. Deng, C. Wang, N. Jonhson, J. Gonzalez, X. Li, L. Metang, C. Rodriguez, A. Mukherji, G. Wainwright, X. Yu, Y. Yang, , T. Wang
This study shows ZNF397 loss leads to TET2-driven epigenetic changes, lineage plasticity, and resistance to AR-targeted therapies in AR-dependent cancers, with TET2 inhibitors reversing resistance.
bioRxiv · Oct 24, 2023Cancer Biology