Author

D. Alexander

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:fungi (other)· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. Sottoriva· 1 shared A.-M. Baker· 1 shared B. Guo· 1 shared B. Werner· 1 shared B. Yu· 1 shared C. D. Steele· 1 shared C. Jin· 1 shared C. Ross· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperCancer Biology

A. Sottoriva

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer

H. Kayhanian, P. Barmpoutis, E. Lakatos, W. C. H. Cross, G. Caravagna, L. Zapata, K. Litchfield, C. D. Steele, W. Waddingham, D. Patel, S. Milite, C. Jin, A.-M. Baker, C. Ross, D. Alexander, , M. Jansen

The paper shows that mutation rate adaptation in MMRd cancers drives immune escape by modulating neoantigen diversity and subclonal mutation rates.

bioRxiv · Mar 6, 2022 · PreprintCancer Biology

Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

M. C. Johnson, G. Can, M. Santos, D. Alexander, P. Zegerman

This study shows that the S-phase checkpoint, via Rad53 kinase, inhibits replication initiation factors beyond S-phase, preventing re-replication and inappropriate gene amplification in G2/M and G1 phases.

bioRxiv · Sep 30, 2020Cell Biology

Carbohydrate, glutathione, and polyamine metabolism are central to Aspergillus flavus oxidative stress responses over time

B. Guo, J. Fountain, L. Yang, M. Pandey, P. Bajaj, D. Alexander, S. Chen, R. Kemerait, R. Varshney

This paper identifies metabolite pathways involved in oxidative stress responses of Aspergillus flavus over time, linking them to aflatoxin production and stress tolerance.

bioRxiv · Jan 3, 2019Microbiology

Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine for production

S. M. O'Rourke, G. Byrne, T. Gwen, W. Meredith, B. Yu, K. A. Mesa, R. C. Doran, D. Alexander, P. W. Berman

This paper develops a gene-edited CHO cell line and robotic selection method to improve Env expression and antigenic structure for HIV vaccine production.

bioRxiv · May 8, 2018Bioengineering