Author

P. Van Loo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Assay:whole-genome sequencing· 4 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2

Frequent Co-Authors

T. Lesluyes· 3 shared J. Demeulemeester· 2 shared K. Haase· 2 shared M. Gerstung· 2 shared M. Tarabichi· 2 shared A. Abbasi· 1 shared A. Baez-Ortega· 1 shared A. Diaz-Lagares· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

T. Lesluyes

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Author profile →

6 papers

Recent·Most cited

Spatiotemporal Genomic Profiling of Intestinal Metaplasia Reveals Clonal Dynamics of Gastric Cancer Progression

K. K. Huang, H. Ma, T. Uchihara, T. Sheng, R. H. H. Chong, F. Zhu, S. Srivastava, S. T. Tay, R. Sundar, A. L. K. Tan, X. Ong, M. Lee, S. W. T. Ho, T. Lesluyes, P. Van Loo, , P. Tan

This study analyzes genomic and transcriptomic data from gastric samples to identify driver genes and clonal dynamics in intestinal metaplasia, showing their progression to gastric cancer and the role of microbial dysbiosis.

bioRxiv · Apr 10, 2023Cancer Biology

Signatures of copy number alterations in human cancer

C. D. Steele, A. Abbasi, A. S. M. Islam, A. Khandekar, K. Haase, S. Hames, M. Tarabichi, T. Lesluyes, A. M. Flanagan, F. Mertens, P. Van Loo, L. B. Alexandrov, N. Pillay

This paper identifies 19 copy number signatures in 9,873 cancers, explaining 93% of TCGA samples, and reveals diverse mechanisms underlying copy number alterations in human cancer.

bioRxiv · Apr 30, 2021Cancer Biology

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

E. G. Alvarez, J. Demeulemeester, C. Jolly, D. Garcia-Souto, P. Otero, A. Pequeno, J. Zamora, M. Tojo, J. Temes, A. Baez-Ortega, B. Rodriguez-Martin, Y. Li, A. Oitaben, A. L. Bruzos, M. Martinez-Fernandez, , J. Tubio

The paper identifies a mutational mechanism in hepatocellular carcinoma driven by Hepatitis B virus DNA integration, leading to genomic restructuring and oncogenic rearrangements.

bioRxiv · Apr 19, 2021Cancer Biology

Biallelic mutations in cancer genomes reveal local mutational determinants

J. Demeulemeester, S. C. Dentro, M. Gerstung, P. Van Loo

The paper identifies biallelic mutations in cancer genomes and highlights their implications for mutation hotspots and variant calling.

bioRxiv · Mar 29, 2021Cancer Biology

An Integrative Analysis of the Age-Associated Genomic, Transcriptomic and Epigenetic Landscape across Cancers

K. Chatsirisupachai, T. Lesluyes, L. Paraoan, P. Van Loo, J. P. de Magalhaes

This study analyzes age-related genomic, transcriptomic, and epigenetic changes across cancers using TCGA data, finding increased genomic instability and mutations in older patients.

bioRxiv · Aug 25, 2020Cancer Biology

Neutral tumor evolution?

M. Tarabichi, I. Martincorena, M. Gerstung, A. M. Leroi, F. Markowetz, P. T. Spellman, Q. D. Morris, O. C. Lingjaerde, D. C. Wedge, P. Van Loo, PCAWG Evolution and Heterogeneity Working Group

The paper explores tumor evolution through subclonal analysis and discusses the role of driver and passenger mutations in cancer progression.

bioRxiv · Jul 23, 2018Cancer Biology