PhysiologybioRxiv
MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention
B. Qiu, A. Lawan, C. E. Xirouchaki…·A. M. Bennett
This study shows MKP1 suppresses AMPK activity via LKB1 nuclear retention, promoting NASH by inducing hepatocyte death and inflammation.
DOI 10.1038/s41467-023-41145-5