C. F. Ibanez

This study identifies a small molecule that inhibits melanoma migration and metastasis by targeting the transmembrane domain of p75NTR, showing promise for cancer treatment.

This study identifies ALK4's role in promoting adipose tissue hyperplasia by inhibiting adipocyte precursor differentiation during obesity.

The paper provides evidence that the death domain of the p75 neurotrophin receptor exists in equilibrium between monomeric and dimeric forms in solution.

This study determines the structure of the p75NTR-DD/TRADD-DD complex and shows TRADD recruitment regulates NF-κB signaling and cell survival in cerebellar granule neurons.

This study shows that combining ALK7 inhibition with lifestyle or anti-inflammatory interventions leads to sustained weight loss in obese mice, even under high caloric intake.

This study identifies ALK7 as a regulator of brown adipose tissue adaptation to nutrient stress by suppressing catabolic responses during fasting.