Author

D. L. Senger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

N. H. Dang· 3 shared D. J. Mahoney· 2 shared F. J. Zemp· 2 shared J. A. Chan· 2 shared S. Morrissy· 2 shared X. Lun· 2 shared A. Abdelkareem· 1 shared A. Gillmor· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCancer Biology

N. H. Dang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma

V. Thoppey Manoharan, A. Abdelkareem, S. Brown, A. Gillmor, C. Hall, H. Seo, K. Narta, S. Grewal, N. H. Dang, B. Y. Ahn, K. Otz, X. Lun, L. Mah, F. J. Zemp, D. J. Mahoney, , S. Morrissy

The paper uses a novel computational workflow to analyze a spatiotemporally profiled GBM xenograft cohort, identifying 15 tumor cell programs related to invasion and their prognostic significance in GBM patients.

bioRxiv · Dec 5, 2023Cancer Biology

Impaired migration and metastatic spread of human melanoma by a novel small molecule targeting the transmembrane domain of death receptor p75NTR

V. Lopes-Rodrigues, S. A. Nyantakyi, X. Lun, J. Zhang, A. Ramanujuan, S. Salim, M. Saleeb, D. L. Senger, C. F. Ibanez

This study identifies a small molecule that inhibits melanoma migration and metastasis by targeting the transmembrane domain of p75NTR, showing promise for cancer treatment.

bioRxiv · Nov 13, 2023 · PreprintCancer Biology

ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97

A. Pozner, S. P. Verma, L. Li, S. Wang, J. J. Barrott, M. L. Nelson, J. S. E. Yu, G. L. Negri, S. Colborne, C. S. Hughes, J.-F. Zhu, S. L. Lambert, L. S. Carroll, K. Smith-Fry, M. G. Stewart, , K. B. Jones

This study identifies VCP/p97 as an obligate co-factor of ASPSCR1-TFE3, showing it organizes enhancer loops to drive oncogenic transcription in ASPS and RCC.

bioRxiv · Sep 29, 2023Cancer Biology

Subclonal architecture, evolutionary trajectories and patterns of inheritance of germline variants in pediatric glioblastoma

M. Hoffman, A. H. Gillmor, D. J. Kunz, M. J. Johnston, A. Nikolic, K. Karta, J. King, K. Ellestad, N. H. Dang, F. M. Cavalli, M. M. Kushida, F. J. Coutinho, B. Luu, Y. Ma, A. J. Mungall, , M. Gallo

This study examines genetic heterogeneity and evolutionary patterns in pediatric glioblastoma using whole-genome sequencing of germline-tumor pairs, revealing subclonal architecture and complex inheritance mechanisms.

bioRxiv · Oct 12, 2018Cancer Biology