Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer
N. Zhao, E. Kabotyanski, A. Saltzman, A. Malovannaya, X. Yuan, L. Reineke, N. Lieu, Y. Gao, D. Pedroza, S. Calderon, A. Smith, C. Hamor, K. Safari, S. Savage, B. Zhang, , J. Rosen
Zotatifin targets EIF4A to suppress TNBC by inhibiting Sox4, inducing interferon response, and reprogramming the tumor immune microenvironment, synergizing with chemotherapy.
bioRxiv · Sep 28, 2023Cancer Biology