Ectopic FVIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma
A. Kapelanski-Lamoureux, Z. Chen, Z.-h. Gao, R. Deng, A. Lazaris, C. Lebeaupin, L. Giles, J. Malhotra, J. Yong, C. Zou, Y. P. de Jong, P. Metrakos, R. W. Herzog, R. J. Kaufman
This study shows that ectopic expression of misfolded BDD-FVIII in hepatocytes promotes hepatocellular carcinoma under high fat diet, independent of viral transduction.
bioRxiv · Jan 19, 2021Cancer Biology