Author

C. Libbrecht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

F. Alikarami· 2 shared K. M. Bernt· 2 shared A. Felmeister· 1 shared A. Lenard· 1 shared B. Manning· 1 shared C. Chen· 1 shared C. Falkenstein· 1 shared C.-h. Chen· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

F. Alikarami

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2 papers

Recent·Most cited

Clonal evolution mediates Menin-inhibitor resistance in KMT2A-rearranged leukemias.

L. Mahdavi, H. Goodrow, F. Alikarami, A. Lenard, S. S. Riedel, C. Libbrecht, I. Bowser, S. K. Tasian, C. Falkenstein, B. Manning, S. Skuli, M. P. Carroll, G. Wertheim, S. Cai, G. McGeehan, , K. M. Bernt

This study shows that Menin-inhibitor resistance in KMT2A-rearranged leukemias arises through clonal evolution, with resistance developing without prior exposure to the inhibitor.

bioRxiv · Mar 16, 2023Cancer Biology

Single-cell multi-omics reveals elevated plasticity and stem-cell-like blasts relevant to the poor prognosis of KMT2A-rearranged leukemia

C. Chen, W. Yu, F. Alikarami, Q. Qiu, C.-h. Chen, J. Flournoy, P. Gao, Y. Uzun, L. Fang, Y. Yu, Q. Zhu, K. Wang, C. Libbrecht, A. Felmeister, I. Rozich, , K. Tan

This study uses single-cell multi-omics to identify lineage plasticity and stem-cell-like blasts in KMT2A-rearranged leukemia, linking these features to poor prognosis in infants.

bioRxiv · Dec 6, 2020 · PreprintCancer Biology