A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney disease
D. J. Jafree, C. Perera, M. Ball, D. Tolomeo, G. Pomeranz, L. Wilson, B. Davis, W. J. Mason, E. M. Funk, M. Kolatsi-Joannou, R. Polschi, S. Malik, B. J. Stewart, K. L. Price, H. Mitchell, , D. A. Long
The paper identifies a unique pericystic endothelium in ADPKD that contributes to microvascular remodelling and impaired perfusion, suggesting vascular targets for early intervention.
bioRxiv · Mar 3, 2024 · PreprintPathology