M. Ball

A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney disease

The paper identifies a unique pericystic endothelium in ADPKD that contributes to microvascular remodelling and impaired perfusion, suggesting vascular targets for early intervention.

Targeting BET Proteins downregulates miR-33a to promote synergy with PIM inhibitors in CMML

This study identifies PIM inhibitors as synergistic with BET inhibitors in myeloid leukemia, showing miR-33a downregulation drives PIM1 upregulation and GM-CSF hypersensitivity as a biomarker for combination therapy.

Exploration of the single-cell transcriptomic landscape identifies aberrant glomerular cell crosstalk in a murine model of WT1 kidney disease

This study uses single-cell RNA sequencing to identify disrupted cell-cell communication in a mouse model of WT1 kidney disease, highlighting non-immunological pathology and suggesting vascular-targeted therapies.

Hematopoietic stem cells fail to regenerate following inflammatory challenge.

This study shows that repeated inflammatory challenges lead to progressive depletion of functional HSCs with no recovery, contributing to age-related hematopoietic decline.

FAIRsharing, a cohesive community approach to the growth in standards, repositories and policies

The paper introduces FAIRsharing, a community-driven resource that evaluates and promotes standards, databases, and repositories to improve data reuse and interoperability in research.

Leveraging single cell RNA sequencing experiments to model intra-tumor heterogeneity

This study introduces a generalized diversity index (GDI) to quantify intra-tumor heterogeneity using single-cell RNA sequencing data and demonstrates its utility across various cancer types and conditions.