Author

D. Moulding

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 2 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 4 Assay:imaging· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Assay:flow cytometry· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

A. S. Woolf· 2 shared B. Davis· 2 shared C. M. Smith· 2 shared C. O'Callaghan· 2 shared D. A. Long· 2 shared D. Cardinale· 2 shared D. J. Jafree· 2 shared G. Pomeranz· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPathology

A. S. Woolf

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney disease

D. J. Jafree, C. Perera, M. Ball, D. Tolomeo, G. Pomeranz, L. Wilson, B. Davis, W. J. Mason, E. M. Funk, M. Kolatsi-Joannou, R. Polschi, S. Malik, B. J. Stewart, K. L. Price, H. Mitchell, , D. A. Long

The paper identifies a unique pericystic endothelium in ADPKD that contributes to microvascular remodelling and impaired perfusion, suggesting vascular targets for early intervention.

bioRxiv · Mar 3, 2024 · PreprintPathology

PI4KIII3β inhibition reduces rhinovirus associated cell shedding and ciliary dysfunction

S. Velkova, A. Petris, D. Lee, D. Cardinale, D. Moulding, R. Williamson, S. Beinke, K. Grace, E. Hessel, N. Belyaev, T. Hoegg, J. Hurst, R. Smyth, C. Smith, P. Freestone, C. O'Callaghan

This study shows that inhibiting PI4KIIIβ reduces rhinovirus replication and ciliated cell loss in respiratory epithelial cultures from healthy and COPD patients.

bioRxiv · Dec 14, 2023 · PreprintCell Biology

Three-dimensional imaging and single-cell transcriptomics of the human kidney implicate perturbation of lymphatics in alloimmunity

D. J. Jafree, B. Stewart, M. Kolatsi-Joannou, B. Davis, H. Mitchell, L. G. Russell, L. Marinas del Rey, W. J. Mason, B. I. Lee, L. Heptinstall, G. Pomeranz, D. Moulding, L. Wilson, T. Wickenden, S. Malik, , D. A. Long

This study uses 3D imaging and single-cell RNA-sequencing to analyze human kidney lymphatics, revealing structural and transcriptional changes in rejecting kidney transplants.

bioRxiv · Oct 28, 2022 · PreprintImmunology

Dynamics and consequences of the HTLV-1 proviral plus-strand burst

S. Ramanayake, D. Moulding, Y. Tanaka, A. Singh, C. R. M. Bangham

This study uses live-cell imaging and mathematical modeling to analyze Tax expression dynamics in HTLV-1 infected T-cells, revealing heterogeneous patterns and impacts on cell behavior.

bioRxiv · Aug 1, 2022Microbiology

Short-term Rho-associated kinase inhibitor treatment accelerates primary keratinocyte growth while preserving stem cell characteristics

V. Jayarajan, G. T. Hall, T. Xenakis, N. Bulstrode, D. Moulding, S. Castellano, W.-L. Di

Short-term ROCKi treatment accelerates keratinocyte growth without compromising stem cell characteristics, suggesting a safe method for clinical applications.

bioRxiv · Jun 28, 2022Cell Biology

Trans-epithelial migration is essential for neutrophil activation during RSV infection

E. Robinson, J. A. Herbert, M. Palor, L. Ren, I. Larken, A. Patel, D. Moulding, M. Cortina-Borja, R. Smyth, C. M. Smith

This study shows that trans-epithelial migration is necessary for neutrophil activation during RSV infection, with three phases of neutrophil behavior identified.

bioRxiv · Oct 4, 2021Immunology

High-content screening for rare respiratory diseases: readthrough therapy in primary ciliary dyskinesia

D. D. H. Lee, D. Cardinale, E. Nigro, C. R. Butler, A. Rutman, M. R. Fassad, R. A. Hirst, D. Moulding, A. Agrotis, E. Forsythe, D. Peckham, E. Robson, C. M. Smith, S. Somavarapu, P. L. Beales, , C. O'Callaghan

The paper develops a high-content screening method using differentiated respiratory epithelium from PCD patients to evaluate readthrough therapies for rare respiratory diseases.

bioRxiv · Feb 28, 2020 · PreprintCell Biology