Author

T. Hummel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:Drosophila· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Kasture· 2 shared M. Freissmuth· 2 shared S. Bhat· 2 shared A. Aronis· 1 shared A. Bonifazi· 1 shared A. El-Kasaby· 1 shared A. Elkasaby· 1 shared A. H. Newman· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. Kasture

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3 papers

Recent·Most cited

Subjective assessment and taste strips testing of gustatory function, at home, and in the lab

T. Green, A. Wolf, A. Oleszkiewicz, A. Aronis, T. Hummel, M. Y. Pepino, M. Y. Niv

The paper compares lab and home-based taste strips tests for gustatory function in healthy subjects, finding similar results between settings but no correlation between self-rated taste ability and test scores.

bioRxiv · Sep 11, 2022 · PreprintPhysiology

A mechanism of uncompetitive inhibition of the serotonin transporter

S. Bhat, A. Elkasaby, A. Kasture, D. Boytsov, J. B. Reichelt, T. Hummel, S. Sucic, C. Pifl, M. Freissmuth, W. Sandtner

This paper identifies ECSI#6 as an uncompetitive inhibitor of the serotonin transporter, showing it preferentially binds to the K+-bound inward-facing conformation and acts as a pharmacochaperone for misfolded variants.

bioRxiv · Aug 11, 2022Pharmacology & Toxicology

A tropane-based ibogaine analog rescues folding-deficient SERT and DAT

S. Bhat, D. A. Guthrie, A. Kasture, A. El-Kasaby, J. Cao, A. Bonifazi, T. Ku, T. Ku, J. B. Giancola, T. Hummel, M. Freissmuth, A. H. Newman

The paper identifies a tropane-based ibogaine analog that rescues folding-deficient SERT and DAT mutants in vitro and in vivo.

bioRxiv · Jul 14, 2020Pharmacology & Toxicology