Author

C. Solorzano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Assay:flow cytometry· 2 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1

Frequent Co-Authors

D. M. Ferreira· 6 shared E. Mitsi· 6 shared J. Reine· 6 shared E. Nikolaou· 5 shared S. Pojar· 5 shared A. D. Hyder-Wright· 4 shared A. M. Collins· 4 shared H. Hill· 4 shared

Activity by Year

2018-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

D. M. Ferreira

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination

E. Mitsi, M. O. Diniz, J. Reine, A. M. Collins, R. Robinson, A. Hyder-Wright, M. Farrar, K. Liatsikos, J. Hamilton, O. Onyema, B. C. Urban, C. Solorzano, T. Lambe, S. J. Draper, D. Weiskopf, , D. M. Ferreira

This study shows that hybrid immunity from infection plus vaccination generates durable lung mucosal immunity, while peripheral vaccination alone does not.

bioRxiv · Jan 25, 2023 · PreprintImmunology

Epithelial micro-invasion by Streptococcus pneumoniae induces epithelial-derived innate immunity during colonisation at the human mucosal surface

C. M. Weight, C. Venturini, S. Pojar, S. Jochems, J. Reine, E. Nikolaou, C. Solorzano, M. Noursadeghi, J. S. Brown, D. M. Ferreira, R. S. Heyderman

This study shows that Streptococcus pneumoniae colonizes human mucosa via microinvasion, triggering epithelial innate immunity and influencing bacterial clearance.

Nature Communications · Jul 16, 2019Peer-reviewedImmunology

Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespan

J. Reine, B. F. Carniel, C. Solorzano, E. Mitsi, S. Pojar, E. Nikolau, E. L. German, A. D. Hyder-Wright, H. Hill, C. Hales, L. Brown, V. Horsley, L. Hughes, S. Zaidi, V. Connor, , S. P. Jochems

This study examines age-related changes in nasal mucosal immune composition and function, finding reduced granulocytes and T cells in young children and older adults, and links pneumococcal colonization to inflammation.

bioRxiv · Mar 14, 2019 · PreprintImmunology

Efficacy of PCV vaccine is primarily mediated by controlling pneumococcal colonisation density

E. L. German, C. Solorzano, S. Sunny, F. Dunne, J. F. Gritzfeld, E. Mitsi, E. Nikolaou, A. D. Hyder-Wright, A. M. Collins, S. B. Gordon, D. Ferreira

This study re-evaluates PCV-13 efficacy using molecular methods, finding reduced colonisation acquisition and density, suggesting vaccine impact is primarily through controlling colonisation density.

bioRxiv · Feb 14, 2019 · PreprintMicrobiology

Defining mucosal immunity using mass cytometry following experimental human pneumococcal challenge

S. P. Jochems, K. de Ruiter, C. Solorzano, A. Voskamp, E. Mitsi, E. Nikolaou, B. F. Carniel, S. Pojar, E. German, J. Reine, A. Soares-Schanoski, H. Hill, R. Robinson, A. D. Hyder-Wright, C. Weight, , D. M. Ferreira

The paper uses mass cytometry to analyze nasal immune cells after pneumococcal challenge, identifying immune changes linked to colonization and host-pathogen interactions.

bioRxiv · Feb 11, 2019Immunology

Trypanosoma brucei colonises the tsetse gut via an immature peritrophic matrix in the proventriculus

C. Rose, N. A. Dyer, A. Casas-Sanchez, A. J. Beckett, C. Solorzano, B. Middlehurst, M. Marcello, M. J. Lehane, I. A. Prior, A. Acosta-Serrano

This study shows Trypanosoma brucei colonizes the tsetse gut via the immature peritrophic matrix in the proventriculus, not directly through the midgut PM.

bioRxiv · Jan 7, 2019Microbiology

Inflammation induced by influenza virus impairs innate control of human pneumococcal carriage

S. P. Jochems, F. Marcon, B. F. Carniel, M. Holloway, E. Mitsi, E. Smith, J. F. Gritzfeld, C. Solorzano, J. Reine, S. Pojar, E. Nikolaou, E. L. German, A. Hyder-Wright, H. Hill, C. Hales, , D. M. Ferreira

This study shows that influenza virus infection impairs innate immune responses to pneumococcal carriage in the nose, increasing bacterial density through cytokine-driven mechanisms.

bioRxiv · Jun 20, 2018Immunology

Effect of Live Attenuated Influenza Vaccine on Pneumococcal Carriage

J. Rylance, W. A. de Steenhuijsen Piters, S. Pojar, E. Nikolaou, E. German, E. Mitsi, S. Jochems, B. Carniel, C. Solorzano, J. Reine, J. Gritzfeld, M. L. J. Chu, K. Arp, A. D. Hyder-Wright, H. Hill, , D. M. Ferreira

This study tests if LAIV affects pneumococcal carriage in humans, finding transient increases in bacterial density but no overall change in acquisition rates.

bioRxiv · Jun 14, 2018Immunology