G. Carraro

A potential acoustic role for CFTR ion channel in conductive hearing loss

This study investigates the role of CFTR in conductive hearing loss by analyzing middle ear cell composition and gene expression in CF and WT mice.

Cell-surface PD-L1 expression identifies a sub-population of distal epithelial cells enriched in idiopathic pulmonary fibrosis

The paper identifies CD274-expressing cells in human lungs that are expanded in IPF and show progenitor-like behavior in ex vivo assays.

Cryobanking of human distal lung epithelial cells for preservation of their phenotypic and functional characteristics.

This study describes a cryobanking method that preserves phenotypic and functional characteristics of human distal lung epithelial cells, including alveolar type 2 pneumocytes.

Epithelial Plasticity and Innate Immune Activation Promote Lung Tissue Remodeling following Respiratory Viral Infection.

This study shows that epithelial plasticity and innate immune activation contribute to lung tissue remodeling after viral infection, protecting against mortality but causing long-term lung dysfunction.

A molecular atlas of proximal airway identifies subsets of known airway cell types revealing details of the unique molecular pathogenesis of Cystic Fibrosis

The paper uses single-cell transcriptomics to analyze proximal airway epithelium in CF and healthy donors, identifying molecular changes linked to CF pathogenesis.

Single cell reconstruction of human basal cell diversity in normal and IPF lung.

The paper uses single-cell RNA sequencing to analyze basal cell diversity in normal and IPF lung, finding increased secretory primed basal cells in IPF and roles for NOTCH2 and NOTCH3 in their regulation.

Senescence of alveolar stem cells drives progressive pulmonary fibrosis

This study shows that senescence of alveolar type 2 stem cells drives pulmonary fibrosis and that targeting p53 or Tgfβ can block fibrogenesis.