Author

Y. Ko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Evolutionary Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Research Focus:cell type annotation· 6 Research Focus:differential expression· 6 Approach:experimental assay· 6 Assay:scRNA-seq· 3 Approach:statistical model· 3 Assay:proteomics· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

B. Deneen· 3 shared B. Lozzi· 3 shared G. Rao· 3 shared P. He· 3 shared A. Jalali· 2 shared A. O. Harmanci· 2 shared A. Serin Harmanci· 2 shared E. Luna-Figueroa· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

B. Deneen

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma

R. N. Curry, Q. Ma, M. F. McDonald, Y. Ko, S. Srivastava, P.-S. Chin, P. He, B. Lozzi, J. Jing, P. Athukuri, S. Wang, A. O. Harmanci, B. Arenkiel, X. Jiang, B. Deneen, , A. Serin Harmanci

The paper identifies hybrid cells in human glioma with both neuronal and glial electrophysiological and transcriptomic features using Patch-sequencing and a new computational tool.

bioRxiv · Mar 2, 2024Cancer Biology

Succinylation of a KEAP1 sensor lysine promotes NRF2 activation

L. Ibrahim, C. Stanton, K. Nutsch, T. Nguyen, C. Li-Ma, Y. Ko, G. C. Lander, L. Wiseman, M. J. Bollong

The paper identifies succinylation of KEAP1 lysine 131 as a mechanism to activate NRF2 transcriptional signaling through metabolic regulation.

bioRxiv · May 8, 2023Cell Biology

Remote neuronal activity drives glioma infiltration via Sema4f

E. Huang-Hobbs, Y.-T. Cheng, Y. Ko, E. Luna-Figueroa, B. Lozzi, K. Taylor, M. McDonald, P. He, H.-C. Chen, Y. Yang, E. Maleki, Z.-F. Lee, S. Murali, M. Williamson, D. Choi, , B. Deneen

This study identifies callosal projection neurons as drivers of glioma infiltration through Sema4F-mediated activity-dependent signaling in mouse and human tumors.

bioRxiv · Mar 15, 2023 · PreprintCancer Biology

Identification of functional immune and neuronal tumor cells in glioma

R. N. Curry, M. F. McDonald, Q. Ma, J. Meyer, I. Aiba, B. Lozzi, A. Cervantes, Y. Ko, E. Luna-Figueroa, D.-J. Choi, Z.-F. Lee, J. Jing, A. O. Harmanci, A. Rosenbaum, P. He, , A. Serin Harmanci

The paper introduces SCRAM, a tool that identifies tumor-specific cell types in glioma with functional properties similar to non-tumor cells.

bioRxiv · Nov 5, 2022 · PreprintCancer Biology

An mTOR-independent Macroautophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration Phenotypes

L. Yoon, R. C. Botham, A. Verhelle, Y. Wu, C. Cole, E. P. Tan, L. A. Massey, P. Sanz-Martinez, C. C. Chou, J. Xu, L. P. Elia, K. Lee, S. R. Labra, G. M. Kline, Q. Xiao, , S. Encalada

The paper identifies CCT020312, an mTOR-independent autophagy activator, which reduces tauopathy and prionopathy neurodegeneration phenotypes by enhancing autophagy flux and clearing protein aggregates.

bioRxiv · Sep 29, 2022 · PreprintCell Biology

Diverse northern Asian and Jomon-related genetic structure discovered among socially complex Three Kingdoms period Gaya region Koreans

P. Gelabert, A. Blazyte, Y. Chang, D. Fernandes, S. Jeon, J. G. Hong, J. Yoon, Y. Ko, V. Oberreiter, O. Cheronet, K. T. Ozdogan, S. Sawyer, S. Yang, E. M. Greytak, J. Kim, , R. Pinhasi

The study reports the first ancient Korean genomes from the Three Kingdoms period, revealing genetic diversity linked to northern Chinese and Japanese Jomon-related ancestry.

bioRxiv · Oct 23, 2021 · PreprintEvolutionary Biology

Clinical and immunological signatures of severe COVID-19 in previously healthy patients with clonal hematopoiesis

C. K. Kang, B. Choi, S. Kim, S. Park, S. H. Yoon, D. Lee, A. Lee, Y. Ko, E. Chang, J. Jung, P. G. Choe, W. B. Park, E. S. Kim, H. B. Kim, N. J. Kim, , I. Jung

This study identifies clonal hematopoiesis as an independent risk factor for severe COVID-19 in previously healthy patients, revealing distinct immunological and epigenetic signatures.

bioRxiv · Oct 5, 2021 · PreprintImmunology

ThiL is a valid antibacterial target that is essential for both thiamine biosynthesis and salvage pathway in Pseudomonas aeruginosa

H. J. Kim, H. Lee, Y. Lee, I. Choi, Y. Ko, S. Lee, S. Jang

This study demonstrates that ThiL is essential for thiamine biosynthesis and salvage in Pseudomonas aeruginosa and identifies inhibitors with potential antibacterial activity.

bioRxiv · Mar 4, 2020Microbiology