Author

C. Haynes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:C. elegans· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Assay:ATAC-seq· 1 Organism:bacteria (other)· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Q. Yang· 3 shared Y. Du· 3 shared P. Chien· 2 shared P. Liu· 2 shared T. Shpilka· 2 shared A. Longchamp· 1 shared B. B. Barros· 1 shared C. Statzer· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCell Biology

Q. Yang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A legacy role for DNA binding of Lon protects against genotoxic stress

R. D. Zeinert, J. Ogdahl, J. Liu, Q. Yang, Y. Du, B. B. Barros, P. L. Freddolino, C. Haynes, P. Chien

The paper shows that Lon protease DNA binding protects bacteria and mitochondria from genotoxic stress by clearing bound proteins.

bioRxiv · Dec 27, 2022 · PreprintMicrobiology

Mitochondrial genome recovery by ATFS-1 is essential for development following starvation

N. U. Naresh, T. Shpilka, Q. Yang, Y. Du, C. Haynes

This study shows that ATFS-1's mitochondrial localization, not its nuclear activity, is essential for mtDNA recovery and development after starvation in C. elegans.

bioRxiv · May 19, 2022 · PreprintCell Biology

ATF-4 and hydrogen sulfide signalling mediate longevity from inhibition of translation or mTORC1

C. Statzer, J. Meng, R. Venz, M. Bland, S. Robida-Stubbs, K. Patel, D. Petrovic, R. Emsley, P. Liu, I. Morantte, C. Haynes, W. B. Mair, A. Longchamp, M. Filipovic, T. K. Blackwell, C. Y. Ewald

The paper shows that ATF-4 and hydrogen sulfide signaling mediate longevity from translation or mTORC1 inhibition in C. elegans.

bioRxiv · Nov 2, 2020 · PreprintPhysiology

mtDNA replication in dysfunctional mitochondria promotes deleterious heteroplasmy via the UPRmt

Q. Yang, P. Liu, N. Anderson, T. Shpilka, Y. Du, N. Uma Naresh, K. Luk, J. Lavelle, R. Zeinert, P. Chien, S. Wolfe, C. Haynes

The paper shows ATFS-1 promotes {Delta}mtDNA replication by recruiting POLG, while LONP-1 inhibition increases wildtype mtDNA binding and improves heteroplasmy ratio and OXPHOS function.

bioRxiv · Sep 1, 2020 · PreprintCell Biology