D. Jonigk

Multimodal single-cell profiling reveals cancer crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients.

This study uses multimodal single-cell profiling to identify immune cell crosstalk mechanisms in poor prognostic cholangiocarcinoma, revealing key ligand pairs and pathways contributing to immune exhaustion.

Cell therapy with human iPSC-derived cardiomyocyte aggregates leads to efficient engraftment and functional recovery after myocardial infarction in non-human primates

This study transplants human iPSC-derived cardiomyocyte aggregates into non-human primates with myocardial infarction, showing efficient engraftment and functional recovery with lower cell doses than previous single-cell approaches.

The use of cultured human alveolar basal cells to mimic honeycomb formation in idiopathic pulmonary fibrosis

The paper uses cultured human alveolar basal cells to create in vitro and in vivo models that mimic honeycomb cyst formation in idiopathic pulmonary fibrosis.

TIGIT drives the immunosuppressive environment by downregulation of metalloproteinases MMP2 and MMP14 in perihilar cholangiocarcinoma.

This study examines TIGIT's role in perihilar cholangiocarcinoma by showing its association with immunosuppressive markers and MMP2/MMP14 downregulation.

Donor tissue-resident memory-like T and NK cells generate a transient peripheral chimerism in lung transplant recipients, potentially protective from chronic lung allograft dysfunction

Donor TRM-like T and NK cells create a temporary chimerism in lung transplant recipients, possibly reducing the risk of chronic lung allograft dysfunction.

Omicron-induced interferon signalling prevents influenza A virus infection

This study shows Omicron variants induce interferon responses in human cells, protecting against influenza A virus super-infection, while Delta does not.

A Multi-scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph Nodes

This study creates a multi-scale, multiomic atlas of human normal and follicular lymphoma lymph nodes to identify tumor-specific features and microenvironmental patterns associated with early relapse.

Ex Vivo Validation of Six FDA-Approved Non-Receptor Tyrosine Kinase Inhibitors (NRTKIs) as Antivirals to Pandemic and Seasonal Influenza A Viruses

The paper tests six FDA-approved non-receptor tyrosine kinase inhibitors for antiviral activity against influenza A viruses in cell cultures and human lung slices, finding potent inhibition of virus replication.

3D virtual Histopathology of Cardiac Tissue from Covid-19 Patients based on Phase-Contrast X-ray Tomography

This study uses phase-contrast x-ray tomography to analyze 3D cardiac tissue structure from Covid-19 patients, revealing distinct vascular changes compared to other viral myocarditides.

Airway Basal Cells show a dedifferentiated KRT17high Phenotype and promote Fibrosis in Idiopathic Pulmonary Fibrosis

This study identifies IPF-ABC as dedifferentiated KRT17high cells that promote fibrosis and shows SRC inhibition can reverse their profibrotic effects.

In vitro culture of aberrant basal-like cells from fibrotic lung tissue

The paper cultures and characterizes aberrant basal-like cells from fibrotic lung tissue, finding they co-express epithelial and mesenchymal markers and show disease-specific transcriptomic differences between IPF and other ILD patients.