M. Busch

The fungal protein Jps1 facilitates unconventional protein secretion through a direct phosphoinositide interaction

This study identifies Jps1 as a key protein facilitating unconventional secretion in Ustilago maydis by interacting with phosphoinositides, revealing its structural and functional roles in Cts1 export.

Cardiac-targeted rAAV5-S100A1 gene therapy protects against adverse remodeling and contractile dysfunction in post-ischemic hearts

This study demonstrates that cardiac-targeted rAAV5-S100A1 gene therapy reduces adverse remodeling and improves contractile function in post-ischemic hearts in pigs and mice.

SUMO interacting motif (SIM) of S100A1 is critical for S100A1 post-translational protein stability

This study identifies a SUMO interacting motif in S100A1 that regulates its post-translational stability through SUMO-mediated interactions.

The periplasmic chaperone Skp prevents misfolding of the secretory lipase A from Pseudomonas aeruginosa

This study shows that Skp prevents misfolding of lipase A in Pseudomonas aeruginosa and facilitates its activation by LipH, with two binding modes identified.

Ex Vivo Validation of Six FDA-Approved Non-Receptor Tyrosine Kinase Inhibitors (NRTKIs) as Antivirals to Pandemic and Seasonal Influenza A Viruses

The paper tests six FDA-approved non-receptor tyrosine kinase inhibitors for antiviral activity against influenza A viruses in cell cultures and human lung slices, finding potent inhibition of virus replication.

Bioorthogonal red and far-red fluorogenic probes for wash-free live-cell and super-resolution microscopy

The paper develops new fluorogenic probes for live-cell and super-resolution microscopy with minimal label size and efficient quenching.

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection

This study fine-maps genetic loci associated with spontaneous clearance of hepatitis C virus infection, identifying a narrower region in the MHC locus and suggesting subtype-specific effects.