Cell BiologyMolecular Biology of the CellPeer-reviewed
Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum functions
Melissa J. Mann, Chris Melendez-Suchi, Hannah E. Vorndran…·Teresa M. Buck
This study shows that loss of Grp170 causes ER dysfunction, including BiP misregulation and UPR activation, leading to cell death in mouse embryonic fibroblasts.
13 citations