J. K. Burkhardt

This study shows that LFA-1 signaling, but not VLA-4, drives cytoskeletal changes enabling T cells to migrate upstream against shear flow.

This study shows that maturation increases dendritic cell cortical stiffness, which enhances T cell activation by reducing agonist dose requirements and is more pronounced in CD4+ T cells.

This study identifies CrkL as essential for donor T cell migration to GvHD target organs, showing that CrkL-deficient T cells cannot migrate into inflamed tissues but can still eliminate hematopoietic tumors.

Hem1 loss-of-function mutations cause congenital immunodysregulation by disrupting WAVE2 and mTORC2 complexes, leading to immunodeficiency and immune hyperresponsiveness.