The lipid Gb3 promotes germinal center B cell responses and anti-viral immunity
P. Sharma, X. Zhang, K. Ly, Y. Zhang, Y. Hu, A. Ye, J. Hu, J. H. Kim, M. Lou, C. Wang, Q. Celuzza, Y. Kondo, K. Furukawa, D. Bundle, K. Furukawa, , F. Winau
The paper shows that Gb3 lipid on GC B cells enhances antibody affinity and breadth, promoting cross-protective immunity against influenza.
bioRxiv · Sep 23, 2023 · PreprintImmunology