K. Ly

The lipid Gb3 promotes germinal center B cell responses and anti-viral immunity

The paper shows that Gb3 lipid on GC B cells enhances antibody affinity and breadth, promoting cross-protective immunity against influenza.

Hyperglycosylation of prosaposin in tumor DCs promotes immune escape in cancer

This study shows that hyperglycosylation of prosaposin in tumor DCs leads to immune escape by impairing antigen presentation and T cell activation.

Leveraging IFNγ/CD38 regulation to unmask and target leukemia stem cells in acute myelogenous leukemia

This paper develops a T cell engager that uses IFNγ to upregulate CD38 on leukemia stem cells, enabling their targeting and depletion in AML.

Early life tolerance depends on a subset of specialized dendritic cells and is reinforced by the skin microbiota

The paper identifies CD301b+ dendritic cells in neonatal skin that promote tolerance to commensal bacteria through regulatory T cell generation, reinforced by microbial interactions.

Microbial signals and lymphotoxin drive TNF-independent death of A20 and ABIN-1 deficient epithelium

The paper shows that microbial signals, MyD88, and lymphotoxin contribute to TNF-independent intestinal injury after A20 and Abin-1 deletion in intestinal epithelial cells.

Late-in-life treadmill-training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts.

This study shows that treadmill training in old mice improves autophagy, protein aggregate clearance, and heart function.

Diet induces reproducible alterations in the mouse and human gut microbiome

This study identifies reproducible gut microbiome changes induced by a high-fat diet in mice and shows that a machine learning model can predict dietary intake in mice and humans.