B. Tran

Use of Stem Cell-Derived Cardiomyocyte and Nasal Epithelium Models to Establish a Multi-Tissue Model Platform to Validate Repurposed Drugs Against SARS-CoV-2 Infection

The paper validates repurposed drugs against SARS-CoV-2 using stem cell-derived cardiomyocyte and nasal epithelium models, confirming fluvoxamine's antiviral efficacy in combination with other drugs.

UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer.

This study identifies UGDH as a driver of tumor-initiating cells and fibroinflammatory microenvironment in ovarian cancer, with subtype-specific effects on prognosis and tumor growth.

Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth

This study identifies Trabid mutations that disrupt APC trafficking and neurite growth by impairing DUB activity or STRIPAK binding, leading to neurodevelopmental defects.

Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.

Uncovering strain- and age-dependent differences in innate immune response to SARS-CoV-2 infection in nasal epithelia using 10X single-cell sequencing

The paper uses single-cell sequencing to compare innate immune responses to SARS-CoV-2 in nasal epithelial cells from adults and adolescents, finding age- and strain-dependent differences.

Single-cell atlas of tumor clonal evolution in liver cancer

This study constructs a single-cell atlas of liver cancer tumor clonality using machine learning and identifies osteopontin as a key driver of tumor evolution and immune reprogramming.

Single-cell profiling of tumor-reactive CD4+ T-cells reveals unexpected transcriptomic diversity

The paper uses single-cell RNA sequencing to reveal diverse transcriptomic patterns in CD4+ T cells responding to tumors, highlighting differences from virus responses and potential implications for immunotherapy.