C. Schultz

A genetically encoded sensor for real-time monitoring of poly-ADP-ribosylation dynamics in-vitro and in cells

This paper introduces a genetically encoded FRET probe (pARS) for real-time monitoring of PARylation dynamics in vitro and in live cells, showing its utility in detecting PARP1 activity and inhibitor potency.

Trifunctional fatty acid derivatives demonstrate the impact of diazirine placement

The paper synthesizes three palmitic acid derivatives with diazirine at different positions and shows that end-position diazirines crosslink distinct protein subsets.

Trace Amines are Essential Metabolites for the Autocrine Regulation of β-Cell Signaling and Insulin Secretion

This study identifies trace amines (TAs) as essential autocrine signaling factors for β-cell activity and insulin secretion, showing their modulation affects intracellular Ca2+ oscillations and insulin release.

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

Estimating butterfly population trends from sparse monitoring data using Generalized Additive Models

The paper develops guidelines for estimating butterfly population trends from sparse data using generalized additive models and introduces an R package for simulating and testing these models.

Trifunctional sphinganine: a new tool to dissect sphingolipid function

The paper develops multifunctional derivatives of sphingosine and sphinganine to study their cellular roles, revealing distinct protein interactomes and spatiotemporal distributions.

Recently evolved combination of unique sulfatase and amidase genes enables bacterial degradation of the wastewater micropollutant acesulfame worldwide

The paper identifies two bacterial genes enabling acesulfame degradation, showing their recent evolution and global spread through plasmid transposition.

Targeting ATP12A, a non-gastric proton pump alpha subunit, for idiopathic pulmonary fibrosis treatment

This study identifies ATP12A as a potential therapeutic target for idiopathic pulmonary fibrosis by showing its overexpression in IPF lungs and its role in worsening fibrosis in mice.

MRI Guided Fresh Tissue Procurement in Radical Prostatectomy Specimens: An Evolutionary Paradigm

This paper evaluates new methods for precise fresh tissue sampling in prostate specimens using 3D-printed molds, showing improved accuracy over traditional surgical estimation.

A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants

The paper identifies glycerolipid biosynthesis as a conserved host dependency factor for SARS-CoV-2 by mapping lipid metabolism changes across variants.

Do demographic processes change at extremely low population size in western monarch butterflies?

The paper examines demographic processes in western monarch butterflies before and after a population crash, finding no evidence for Allee effects but noting a decline in overwinter survival and range expansion.

Incorporation of unnatural amino acid for the tagging of cannabinoid receptors 1 and 2 reveals receptor roles in regulating cAMP levels

This study uses unnatural amino acid incorporation to tag CB1 and CB2 receptors, revealing their distinct and opposing roles in regulating intracellular cAMP levels when co-expressed.

Dynamic trafficking and turnover of Jam-C is essential for endothelial cell migration

The paper identifies Jam-C trafficking and ubiquitylation by CBL as essential for endothelial cell migration and junctional remodelling during angiogenesis.

A combinatorial extracellular code tunes the intracellular signaling network activity to distinct cellular responses

The paper investigates how combinatorial extracellular cues influence intracellular signaling network activity and cellular responses in human cells.